Tag: M.W=250-300

Gomez Guillen, M. published the artcileSynthesis of (pentahydroxypentyl)pyrazoles by reaction of D-galactose arylhydrazones with 2-nitro-1-phenylalkenes, Computed Properties of 13599-22-9, the publication is Anales de Quimica, Serie C: Quimica Organica y Bioquimica (1986), 82(3), 204-10, database is CAplus.

The reactions of aldehydo–D-galactose phenylhydrazones I (R = Ph) with β-nitrostyrene II (R¹ = H, Me) gave diphenylpyrazoles III (R = Ph, R¹ = H, Me); similarly I (R = p-MeC₆H₄) and II (R¹ = Me) gave III (R = p-MeC₆H₄, R¹ = Me). I (R = p-MeC₆H₄) and II (R¹ = H) gave tolylpyrazole IV showing the reverse regiochem. to that previously observed III and IV were converted to pentaacetates or oxidized by IO₄^– to pyrazole-3-carboxaldehydes which were then converted to carboxylic acids by moist Ag₂O.

Anales de Quimica, Serie C: Quimica Organica y Bioquimica published new progress about 13599-22-9. 13599-22-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid,Benzene, name is 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, and the molecular formula is C16H12N2O2, Computed Properties of 13599-22-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Liu, Chong-Bo published the artcileSyntheses, Characterization, and Antibacterial Activities of Four New Schiff Base Compounds Derived from 1-Phenyl-3-methyl-4-benzoyl-2-pyrazolin-5-one, Product Details of C17H14N2O2, the publication is Journal of Heterocyclic Chemistry (2012), 49(4), 839-844, database is CAplus.

Four new Schiff bases were designed and synthesized. 5-Methyl-4-(4-aminophenylamino-phenyl-methylene)-2-phenyl-2,4-dihydro-pyrazol-3-one (compound 1) and 5-methyl-4-(2-aminophenylamino-phenyl-methylene)-2-phenyl-2,4-dihydro-pyrazol-3-one (compound 2) were synthesized by interaction of 1-phenyl-3-methyl-4-benzoyl-2-pyrazolin-5-one (PMBP) with o- and p-phenylenediamine, resp.; 4,4′-(1,2-phenylenebis(azanediyl)bis(phenylmethanylylidene))bis(3-methyl-1-phenyl-1H-pyrazol-5(4H)-one) (compound 3) and 5-methyl-4-(phenyl(2-((3-phenylallylidene)amino)phenylamino)methylene)-2-phenyl-2,4-dihydro-pyrazol-3-one (compound 4) were synthesized by interaction of compound 2 with PMBP and cinnamaldehyde in an ethanolic medium, resp. The mol. structures of the title compounds were first characterized by single-crystal X-ray diffraction, mass spectrometry, and elemental anal. The title compounds were tested for antibacterial activity (Escherichia coli, Staphylococcus aureus, and Bacillus subtilis) by disk diffusion method.

Journal of Heterocyclic Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Product Details of C17H14N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Song, Fu-Qiang published the artcileConstruction of enhanced fluorescence sensors in aqueous media by cation regulation and hybridization, HPLC of Formula: 4551-69-3, the publication is Journal of Luminescence (2021), 118338, database is CAplus.

For sensing application, a salicylacylhydrazone (H₂L) with multiple binding sites which was condensed by salicylhydrazide and 4-acylpyrazolone, H₂L = 4-Benzoyl-3-methyl-l-phenyl-5-pyrazolone-benzoic acid hydrazide was prepared Fluorescence studies indicate that H₂L could be used as turn-on sensors to distinguish between Cd²⁺ and Zn²⁺ in Hepes buffer solution (pH = 6.8) and the origin of the specificity of the fluorescence recognition was disclosed through 1H NMR spectra, UV-Vis spectra, ESI mass spectra, X-ray single crystal diffraction and DFT calculations H2L test silica sheets were further prepared to offer easy and real-time detection of Cd²⁺ and Zn²⁺ ions. Furthermore, the in situ system generated from the sensing of Zn²⁺ and Cd²⁺ (ZnHL and CdHL) showed good relay recognition ability for picric acid (PA) via fluorescence quenching. The recognition mechanism of PA could be attributed to the multi-quenching mechanism dominated by the competitive absorption with PET effect and hydrogen bond being assistance when d. functional theory calculations and multiple exptl. evidences, including ESI mass spectrum, 1H NMR spectra as well as UV-Vis absorption are combined. To enhance their sensing ability together with the convenience of detection, the hybrid films of ZnHL@PMMA and CdHL@PMMA are prepared by doping them to polymethyl methacrylate (PMMA) matrix to improve their fluorescence performance, chem. stability, sensitivity, cheapness and quickness.

Journal of Luminescence published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C8H7NaO4S, HPLC of Formula: 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Yu, Hui published the artcileSynthesis, characterization and properties of rare earth complexes with pyrazolone and 2,6-pyridinecarboxylic acid, Application In Synthesis of 4551-69-3, the publication is Zhongguo Xitu Xuebao (2014), 32(3), 328-337, database is CAplus.

The four new solid ternary complexes of rare earth with 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone and 2,6-pyridinecarboxylic acid, Na₂[RE(PMBP)₃(PDA)]·nH₂O (RE = Sm³⁺, Y³⁺, Er³⁺, the La-complex including one coordinated water), were synthesized and characterized by elemental anal., FTIR, UV-visible, XRD, TG-DTA and XPS. The antibacterial activities test indicated that all the complexes exhibited moderate antibacterial ability against Escherichia coli and Staphylococcus aureus. also studied the interactions of the Er-complex with calf thymus DNA (CT DNA) employing florescence spectroscopic and UV spectrum. DNA interaction studies suggested the Er-complex could intercalate between DNA base pairs. The Sm-complex might be used as fluorescent probe.

Zhongguo Xitu Xuebao published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C6H13I, Application In Synthesis of 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Maurya, R. C. published the artcileDioxomolybdenum(VI) chelates of bioinorganic, catalytic, and medicinal relevance: Studies on some cis-dioxomolybdenum(VI) complexes involving O, N-donor 4-oximino-2-pyrazoline-5-one derivatives, Category: pyrazoles-derivatives, the publication is Arabian Journal of Chemistry (2015), 8(3), 293-306, database is CAplus.

A new series of five mixed-ligand complexes of dioxomolybdenum(VI) of the general composition [MoO₂(L)₂(H₂O)₂], where LH = 4-acetyloxime-3-methyl-1-phenyl-2-pyrazolin-5-one (aomppH), 3-methyl-1-phenyl-4-propionyloxime-2-pyrazolin-5-one (mppopH), 4-butyryloxime-3-methyl-1-phenyl-2-pyrazolin-5-one (buomppH), 4-iso-butyryloxime-3-methyl-1-phenyl-2-pyrazolin-5-one (ibuomppH) or 4-benzoyloxime-3-methyl-1-phenyl-2-pyrazolin-5-one (bomppH) was synthesized by the interaction of [MoO₂(acac)₂] with the said ligands in ethanol medium. The complexes so obtained were characterized by elemental analyses, molar conductance, decomposition temperature and magnetic measurements, thermogravimetric analyses, ¹H NMR, IR, mass, and electronic spectral studies. The 3D mol. modeling and anal. for bond lengths and bond angles also were carried out for one of the representative compound, [MoO₂(aomppH)₂(H₂O)₂] to substantiate the proposed structure.

Arabian Journal of Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Category: pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Yan, Li published the artcileSynthesis of tolidine-PMBP and its complexes, Recommanded Product: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Hecheng Huaxue (2012), 20(3), 386-388, database is CAplus.

Two novel Schiff bases, tolidine-PMBP (L‘) and tolidine-bisPMBP (L), were synthesized from ortho-tolidine and 1-phenyl-3-methyl-4-benzoyl-pyrazolone (PMBP) by solid method. Three complexes of L with Co(II), Cu(II) or Ni(II) were prepared The structures were characterized by UV, ¹H NMR, IR and elemental anal.

Hecheng Huaxue published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C8H6F3NO, Recommanded Product: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Li, Xiao-jing published the artcileCu(II) and Zn(II) complexes with an acylhydrazone derived from 4-methyl salicylic hydrazide and PMBP: crystal structures and fluorescence properties of Zn(II) complex, Name: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Wuji Huaxue Xuebao (2015), 31(8), 1661-1666, database is CAplus.

Two complexes [(Cu)(L)(Cl)]·0.5EtOH·1.5H₂O and {[Zn(L)(NO₃)]·2CH₃CN}_n (HL was the acylhydrazone ligand derived from 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone (PMBP) and 4-Me salicylic hydrazide) had been synthesized and characterized by single-crystal X-ray diffraction, elemental anal. and IR spectroscopy. X-ray diffraction anal. results showed that the coordination geometry of the Cu(II) ion in 1 was a distorted square planar geometry with nitrogen and two oxygen atoms provided by the enolizated ligand L^-1 and one chloride anion. However, in complex 2, the Zn(II) ion with a distorted trigonal biyramid coordination geometry was five-coordinated, involving one nitrate anion, one NO₂ donor set of an enolizated ligand L^– and one pyrazoline nitrogen atom from another adjacent acylhydrazone ligand, thus forming one dimension chain-like framework along b axis. When excited at 310 nm, complex 2 exhibited two strong emissions at 434 and 459 nm, while the ligand showed relatively weak emission at 521 nm. In addition, luminescent decay data showed that the mean lifetime (τ) were 7.3528 and 7.7556 μs for HL and complex 2, resp. CCDC: 1058420, HL·0.5EtOH; 1058421, 1; 1058422, 2.

Wuji Huaxue Xuebao published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Name: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Zhao, Pihong published the artcilePlutonium(IV) and (V) Sorption to Goethite at Sub-Femtomolar to Micromolar Concentrations: Redox Transformations and Surface Precipitation, Name: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Environmental Science & Technology (2016), 50(13), 6948-6956, database is CAplus and MEDLINE.

Pu(IV) and Pu(V) sorption to goethite was investigated over a concentration range of 10^-15-10^-5 M at pH 8. Experiments with initial Pu concentrations of 10^-15 – 10^-8 M produced linear Pu sorption isotherms, demonstrating that Pu sorption to goethite is not concentration-dependent across this concentration range. Equivalent Pu(IV) and Pu(V) sorption K_d values obtained at 1 and 2-wk sampling time points indicated that Pu(V) is rapidly reduced to Pu(IV) on the goethite surface. Further, it suggested that Pu surface redox transformations are sufficiently rapid to achieve an equilibrium state within 1 wk, regardless of the initial Pu oxidation state. At initial concentrations >10^-8 M, both Pu oxidation states exhibited deviations from linear sorption behavior and less Pu was adsorbed than at lower concentrations NanoSIMS and HRTEM anal. of samples with initial Pu concentrations of 10^-8 – 10^-6 M indicated that Pu surface and/or bulk precipitation was likely responsible for this deviation. In 10^-6 M Pu(IV) and Pu(V) samples, HRTEM anal. showed the formation of a body centered cubic (bcc) Pu₄O₇ structure on the goethite surface, confirming that reduction of Pu(V) had occurred on the mineral surface and that epitaxial distortion previously observed for Pu(IV) sorption occurs with Pu(V) as well.

Environmental Science & Technology published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C6H17NO3Si, Name: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Venturella, Pietro published the artcileReactivity of the flavonic ring. I. Action of phenylhydrazine, Computed Properties of 13599-22-9, the publication is Annali di Chimica (Rome, Italy) (1961), 34-44, database is CAplus.

A pyrazoline derivative, C₂₁H₁₈ON₂ was obtained from flavanone (I) by action of NH₂NHPh (II) and its structure was studied by an oxidizing demolition and a direct synthesis. Pure I (0.5 g.) in 5 cc. AcOH was treated with 0.3 g. II to yield after 12 hrs. at room temperature the phenylhydrazone (III), m. 146-7° (EtOH). I (0.5 g.) in 5 cc. AcOH and 0.3 g. II, refluxed 1 hr., the mixture cooled, filtered, and the product crystallized (EtOH) gave 3-(o-hydroxyphenyl)-1,5-diphenylpyrazoline (IV), m. 164-5°. I and II, melted in a test tube, gave IV. 2-Hydroxychalcone (V) (0.5 g.) in 10 cc. AcOH with 0.35 g. II after 2-3 days at room temperature gave IV. V (1 g.) in 15 cc. EtOH refluxed 3 hrs. with 0.6 g. II, cooled, and the product crystallized (EtOH) gave IV. V (0.2 g.) melted with II in excess gave IV. IV (0.5 g.) with 5 cc. Ac₂O and 1 g. AcOMe refluxed 1.5 hrs., poured into H₂O, and the product crystallized gave 3-(o-acetoxyphenyl)-1,5-diphenylpyrazoline (VI), m. 111-12°. 3-(o-Hydroxy-phenyl)-1,5-diphenylpyrazole (VII), m. 105-6°, was prepared from o-hydroxydibenzoylmethane and II. Analogously was prepared 5-(o-hydroxyphenyl)-1,3-diphenylpyrazole (VIII), m. 162-3°. VII (1 g.) in 20 cc. EtOH with metallic Na in excess refluxed 2 hrs. and the product crystallized gave IV. Boiling 1 g. IV in 30 cc. 0.5N NaOH with 7 g. KMnO₄ in 50 cc. H₂O gave 1,5-diphenyl-3-pyrazolecarboxylic acid. Ultraviolet and infrared spectra of IV, VI, VII and VIII were given.

Annali di Chimica (Rome, Italy) published new progress about 13599-22-9. 13599-22-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid,Benzene, name is 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, and the molecular formula is C18H26ClN3O, Computed Properties of 13599-22-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Fusco, Raffaello published the artcileEnamines. V. Synthesis of 1-arylpyrazoles, Recommanded Product: 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, the publication is Gazzetta Chimica Italiana (1961), 1233-49, database is CAplus.

cf. CA 56, 14018c. Enamines and halogenated hydrazones reacted to give pyrazole derivatives In anhyd, conditions 16.7 g. 1-morpholinocyclohex-l-ene (I), 10.1 g. NEt₃, 150 mL. CHCl₃, and 22.6 g. PhNHN: CClCO₂Et added in 50 mL. CHCl₃ was stirred and heated to 40° for 1 h. and kept overnight to give 65% 1-phenyl-3-carbethoxy-4,5,6,7-tetrahydroindazole (II) m. 103-4.5° (EtOH), hydrolyzed by alc. NaOH to 1-phenyl-4,5,6,7-tetrahydroindazole-3-carboxylic acid, m. 164° (AcOH). Similarly, the p-chlorophenyl compound, m. 139-40°, and its corresponding acid m. 218°. Treatment of I with PhNHN:CClAe gave 1-phenyl-3-acetyl-4,5,6,7-tetrahydroindazole, m. 95-6°; phenylhydrazone m. 216° (dilute AcOH). 1-Morpholino-4-methylcyclohex-1-ene gave the 5-Me deriv, of II, m. 129°, hydrolyzed to the corresponding acid m. 198°. 1-Phenyl-3-carbethoxy-4,5,6,7-tetrahydrocydohepta[c]pyrazole (III), m. 87% was prepared from 1-morpholinocyclohept-1-ene and was hydrolyzed to the corresponding acid, m. 166-8°. The 1-(p-chlorophenyl) compd, corresponding to III could not be isolated and was hydrolyzed to the acid, m. 206-7°. From 2 morpholino-3,4-dihydronaphthalene and PhNHN: CClCO₂Et, 1-phenyl-3-carbethoxy-8,9-dihydronaphtho[1,2-c]pyrazole, m. 154-5°, was prepared, giving the acid, m. 170°, on hydrolysis: when decarboxylated at 240°, this gave 1-phenyl-8,9-dihydronaphtho[1,2-c]pyrazole, m. 118°. The compound formed from 1-morpholinocyclopent-1-ene and PhNHN:-CClCO₂Et was an intermediate, C₁₉H₂₅N₃O₃, m. 130° (ale.), converted into the expected 1-phenvl-3-carbethoxy-4,5-dihydrocyclopenta[c] pyrazole, m. 143°. on boiling with AcOH followed by precipitation by addition of water. The corresponding acid, m. 211°; Me ester m. 139°. Similarly the 1-(p-chlorophenyl) compd, gave an adduet, C₁₉H₂₄ClN₃O₃, m. 114° cyclized to the pyrazole, m. 120-1°, which in turn was hydrolyzed to the corresponding free acid, m. 215-16°. Similarly were prepared 1-phenyl-3-carbethoxyindeno[1,2-c]-pyrazole, m. 162-3° (the acid m. 256°), 1-phenyl-3-carbethoxy-4-ethylpyrazole, m. 70° (free acid m. 138°), 1-phenyl-3-carbethoxy-4-n-amylpyrazole, m. 45-6° (free acid m. 121°), [the corresponding 1-(p-chlorophenyl) compd, m. 62° (free acid m. 115°)]. From 2-N-methyl-N-phenyl-amino-4-methylpent-l-ene, the ester prepd, was an oil, b₂ 186°, which gave 1-phenyl-5-isobutylpyrazole-3-carboxylic acid, m. 129°, on hydrolysis, α-(N-Methyl-N-phenyl)-aminostyrene and PhNHN:CClCO₂Et after reaction, evapn, of solvent, steam distn, to remove PhAe, and hydrolysis gave 1,5-diphenylpyrazole-3-carboxylic acid, m. 183°. 1-Phenyl-3-carbethoxy-4-γ-methylaminoethyl-5-methylpyrazole oxalate, m. 174-5° (iso-PrOH), was prepared from 1,2-dimethyl-4,5-dihydropyrrole and gave the corresponding base, as a straw-colored oil, b_1.5 220-40°, which on hydrolysis with 40% HBr gave the free carboxylic acid of the base after addition of Ag₂O to precipitate AgBr, filtration, and passage of H₂S to decomp, the Ag salt; the filtrate evaporated to dryness and the solid washed with MeOH and recrystallized from water gave the acid, m. 297°. 1-Phenyl-3-carbethoxy-4-γ-methylaminopropyl-5-methylpyrazole-HCl, m. 186-7° (iso-PrOH), 1-phenyl-4-γ-methylaminopropyl-5-methylpyrazolecarboxylic acid, m. 270-1° (5% aqueous EtCO-Me), and 1-phenyl-3-acetyl-4-γ-methylaminopropyl-5-methylpyrazole oxalate, m. 17,5-6°, were also prepared

Gazzetta Chimica Italiana published new progress about 13599-22-9. 13599-22-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid,Benzene, name is 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, and the molecular formula is C16H12N2O2, Recommanded Product: 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics