Tag: M.W:200-300

330792-70-6, Adding a certain compound to certain chemical reactions, such as: 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 330792-70-6.

5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (28 mg, 0.1 mmol)A mixture of 2-Bromomalonaldehyde (15 mg, 0.1 mmol) in EtOH (5 mL) was stirred at room temperature for 2 hours.The mixture was then filtered to give a crude yellow solid (20 mg, 62.9percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 39806-90-1

General procedure: 4-Iodo-1-methyl-1H-pyrazole 1 (101 mg, 0.5 mmol) and phenylboronic 2 (59 mg, 0.5 mmol) were dissolved in DME (3 mL) and H2O (1.2 mL) in a microwave vial under a nitrogen atmosphere. Pd(PPh3)4 (2 mmol%, 11.6 mg) and Cs2CO3 (407.3 mg, 1.25 mmol) were added, and the reaction mixture was irradiated in a microwave apparatus at 90 C for 5-12 min. After the reaction mixture was cooled to ambient temperature, the product was concentrated, and the crude mixture was purified by silica gel column chromatography using petroleum ether/acetone as eluent to give the title compound.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 39806-90-1.

1145-01-3, A common compound: 1145-01-3, name is 3,5-Diphenyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Potassium hydroxide (0.800 g, 14 103 mol) was treated with 9.0 mL of DMSO and the resulting mixture was magnetically stirred at room temperature (ca. 298 K) for 30 min. After this period 3,5-diphenylpyrazole (0.788 g, 3.58 103 mol) was added and the stirring was maintained for 30 min at 298 K. Then, 1-chloro-2-methoxyethane (4.0 mL, 45 103 mol) was gradually added and the reaction mixture was left overnight under stirring at 298 K. After this period, 50 mL of iced cold water was added to eliminatethe unreacted KOH; the organic phase was then extracted with diethylether and washed repeatedly with water, dried over Na2SO4 and filtered. Then, the filtrate was concentrated to dryness on arotary evaporator. The solid formed was collected and later on dried in vacuum for 3 days. [Yield: 0.880 g, (88%)]. Characterization data:Anal (%). Calc. for C18H18N2O (MW 278.35): C, 77.67; H, 6.52; N,10.06%; found: C, 77.8; H, 6.6 and N, 10.1. MS (ESI): m/z 279.15{[M] H}. IR selected data: 3059-3015 [n(CeH)] and 2987-2952[n(CeH)], 1481(m), 1462(s), 1441(m), 1363(m), 1300(m), 1115(s),1012(m), 762(s), 691(s) cm1. UV-vis data (c 5.74 x 10-5 M in CH2Cl2): l (epsilon) 223 (1.5 104) and 253 (3.1 104). Rf (inCHCl3) 0.24. 1H NMR data: d 3.32 (s, 3H, OMe); 3.91 [t,3JH,H 7.2, 2H, (-CH2-d)]; 4.34 [t, 3JH,H 7.2, 2H, (-CH2-c)]; 6.65(s, 1H, H4); 7.35 (t, 3JH,H 7.7, 1H, H4b); 7.47e7.60 (m, 5H, H3a, H4a,H5a, H3b and H5b); 7.70 (d, 2H, 3JH,H 7.6, H2b and H6b), 7.92 (d, 2H,3JH,H 7.5, H2a and H6a). 13C{1H} NMR data: 49.1 (Cd); 58.9 (OMe);71.4 (Cc); 103.4 (C4); 125.3 (C2b and C6b); 125.7 (C2a and C6a); 126.0(C4b); 126.8 (C4a); 128.7 (C3a and C5a); 129.2 (C3b and C5b); 130.7(C1b); 133.6 (C1a); 145.9 (C5) and 150.9 (C3).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Diphenyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

141573-95-7, A common compound: 141573-95-7, name is Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

The alkali solution was warmed to 55 C, was added dropwise to the organic layer obtained in step c, the reaction 1h; then recovered the organic solvent, the aqueous layer was retained, the aqueous layer acidified at a temperature of 80 25min, natural cooling To 30 , then water-cooled to 15 , incubated for 30min, filtered and dried to obtain finished DFPA.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

18048-64-1, The chemical industry reduces the impact on the environment during synthesis 18048-64-1, name is 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, I believe this compound will play a more active role in future production and life.

A solution of 3′-amino-2′-hydroxy-1 ,1 ‘-biphenyl-3-carboxylic acid hydrochloride salt (1 .31 g 5.725 mmol) in methanol water, obtained as described in Example 4’, was cooled to 0-5 C and a solution of sodium nitrite (0,403 g, 5.840 mmol) in water (2 ml) was added over 15 minutes. The reaction was stirred at 0-10 C for one hour and then it was heated to 20 C. Triethylamine (about 2,5 ml) was added to bring the pH to 8-9 and 1 -(3,4- dimethylphenyl)-3-methyl-1 H-pyrazol-5-ona (1 .16 g, 5,725 mmol) was added in one portion. The mixture was stirred for 2 hours at 20 C maintaining the pH 8-9. Hydrochloric acid (4M, about 4 ml) was added to adjust the pH to 1 .5- 2.0. The precipitate was filtered, washed with water and dried at 40 C to yield 2.492 g (93%).

The chemical industry reduces the impact on the environment during synthesis 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one. I believe this compound will play a more active role in future production and life.

39806-90-1, These common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Step 2: 1-[(1-methyl)-4-pyrazolyl]ethanone 1-methyl-4-iodopyrazole (10 g), vinyl-n-butyl ether (24 g), palladium acetate (396 mg), 1,3-bi(diphenyl phosphine)propane (988 mg), sodium carbonate (12.7 g) and n-butylalcohol (100 mL) were added in a round bottomed flask (250 mL). The mixture was refluxed under an argon atmosphere for 4 h, cooled to room temperature, filtrated and treated under reduced pressure to remove solvent thereof. The residue was purified by column chromatography (dichloromethane: methanol=50: 1) to get 1-[(1-methyl)-4-pyrazolyl]ethanone (2.4 g) as yellowish solid. 1H-NMR (300Hz, CDCl3) delta: 7.88 (s, 1H), 7.85 (s, 1H), 3.93 (s, 3H), 2,42 (s, 3H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 39806-90-1.

A common compound: 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 92525-10-5

General procedure: To the solution of protected pyrazole 2a-c, 7a, 8a, 12a, 17, 18 or 10a (1 mmol) in 2 mL of dry THFPdCl2(PPh3)2 (14.04 mg, 0.02 mmol) and triethylamine (0.25 g, 2.5 mmol) were added. Reactionmixture was flushed with argon and acetylene (1.2 mmol) were added to the reaction mixturedropwise, following by addition of CuI (1.9 mg, 0.01 mmol) and left to stir at room temperatureovernight. 5 mL of deionized water were added to the reaction mixture, organic layer was separatedand product was extracted with dichloromethane (2 ¡Á 5 mL), organic layers were combined andwashed with 5 mL of water, dried with anhydrous Na2SO4 and evaporated under reduced pressure.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 92525-10-5, other downstream synthetic routes, hurry up and to see.

Some common heterocyclic compound, 83-10-3, name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, molecular formula is C12H12N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 83-10-3

Step 2) 4-((6-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)pyridin-3-yl)oxy)picolinamide To a suspension of 4-((6-aminopyridin-3-yl)oxy)picolinamide (230 mg, 1 mmol) and 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (237 mg, 1.02 mmol) in DCM (5 mL) was added EDCI (230 mg, 1.2 mmol) and HOAT (27 mg, 0.2 mmol). The reaction was stirred at 45 C. for 28 hours, then cooled to rt and diluted with water (10 mL) and DCM (20 mL). The organic phase was concentrated in vacuo and the residue was purified by a silica gel column chromatography (DCM/CH3OH (v/v)=40/1) to give the title compound as a light grey solid (111 mg, 25%). MS (ESI, pos. ion) m/z: 445.1 [M+H]+; 1H NMR (400 MHz, DMSO-d6): delta (ppm) 2.72 (s, 3H), 3.33 (s, 3H), 7.20-7.22 (dd, J=2.64 Hz, 5.64 Hz, 1H), 7.43-7.46 (m, 3H), 7.52-7.54 (m, 1H), 7.58-7.62 (m, 2H), 7.72 (s, 1H), 7.75-7.78 (dd, J=2.88 Hz, 8.96 Hz, 1H), 8.13 (s, 1H), 8.27-8.28 (d, J=2.68 Hz, 1H), 8.34-8.36 (d, J=9.08 Hz, 1H), 8.52-8.54 (d, J=5.6 Hz, 1H), 11.26 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 83-10-3, its application will become more common.

39806-90-1, A common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, molecular formula is C4H5IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: First, Pd/AlO(OH) NP catalyst (40.0 mg, 0.16 mmol %) and 1 mL of H2O/MeOH (v/v = 1/1) were added to a Schlenk tube. Next, the halogenated compound (0.25 mmol) was added. Finally, NaBH4 (0.75 mmol) was added to the reaction mixture and the vessel was closed. The reaction then continued during vigorous stirring under ultrasonic conditions at room temperature and was monitored by GC. Most of the reactions were completed over a time period of 1.5 – 4 h. After completion of the reaction, the catalyst was removed via simple centrifugation at 6000 rpm and then washed three times with methanol and water and allowed to dry for further use. The solvent was evaporated under vacuum. The products were purified by flash column chromatography and the dehalogenated products were then determined by 1H NMR.

The synthetic route of 4-Iodo-1-methyl-1H-pyrazole has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 83-10-3 as follows. 83-10-3

To a suspension of 4-amino-5-chloro-2-fluorophenol (0.97 g, 6 mmol), 1,5- dimethyl-3-oxo-2-phenyl-2,3-dihydro-lH-pyrazole-4-carboxylic acid (1.42 g, 6.12 mmol) in DMF (20 mL) was added EDCI (0.38 mg, 7.2 mmol) and HOAT (0.16 g, 1.2 mmol). The reaction mixture was heated to 80 C and stirred for 24 hours, then cooled to 0 C, and diluted with H20 (200 mL) and EtOAc (2 mL) at 0 C. The resulted mixture was filtered to give the title compound as a light brown solid (1.2 g, 53.2%). MS (ESI, pos. ion) m/z: 376.1 [M+H]+; NMR (400 MHz, DMSO-i): delta 2.68 (s, 3H), 3.34 (s, 3H), 7.03 (d, J= 8.8 Hz, 1H), 7.41-7.43 (m, 2H), 7.48-7.52 (m, 1H), 7.56-7.60 (m, 2H), 8.31 (d, J= 13.8 Hz, 1H), 10.08 (s, 1H), 10.95 (s, 1H).

According to the analysis of related databases, 83-10-3, the application of this compound in the production field has become more and more popular.