Tag: 0-100

《Structure-antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety》 was published in RSC Advances in 2022. These research results belong to Ohta, Kaito; Fushimi, Tetsuya; Okamura, Mutsumi; Akatsuka, Akinobu; Dan, Shingo; Iwasaki, Hiroki; Yamashita, Masayuki; Kojima, Naoto. Electric Literature of C4H6N2 The article mentions the following:

We studied hybrid mols. of annonaceous acetogenins and mitochondrial complex I-inhibiting insecticides to develop a novel anticancer agent. A structure-antitumor activity relationship study focusing on the connecting groups between the heterocycles and the linker moiety bearing the THF moiety was conducted. Eleven hybrid acetogenins with 1-methylpyrazole instead of γ-lactone were synthesized and their growth inhibitory activities against 39 human cancer cell lines were evaluated. The nitrogen atom at the 2′-position of the linker moiety was essential for inhibiting cancer growth. The 1-methylpyrazole-5-sulfonamide analog showed potent growth inhibition of NCI-H23, a human lung cancer cell line, in a xenograft mouse assay without critical toxicity. Hence, the results of this study may pave the way for the development of novel anticancer agents, with both selective and broad anticancer activities. In the experiment, the researchers used 1-Methylpyrazole(cas: 930-36-9Electric Literature of C4H6N2)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Electric Literature of C4H6N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Gas Chromatography-Mass Spectrometry Quantification of 1,1-Dimethylhydrazine Transformation Products in Aqueous Solutions: Accelerated Water Sample Preparation》 was published in Molecules in 2021. These research results belong to Popov, Mark S.; Ul’yanovskii, Nikolay V.; Kosyakov, Dmitry S.. Safety of 1-Methylpyrazole The article mentions the following:

The use of highly toxic rocket fuel based on 1,1-dimethylhydrazine (UDMH) in many types of carrier rockets poses a threat to environment and human health associated with an ingress of UDMH into wastewater and natural reservoirs and its transformation with the formation of numerous toxic nitrogen-containing products. Their GC-MS quantification in aqueous samples requires matrix change and is challenging due to high polarity of analytes. To overcome this problem, accelerated water sample preparation (AWASP) based on the complete removal of water with anhydrous sodium sulfate and transferring analytes into dichloromethane was used. Twenty-nine UDMH transformation products including both the acyclic and heterocyclic compounds of various classes were chosen as target analytes. AWASP ensured attaining near quant. extraction of 23 compounds with sample preparation procedure duration of no more than 5 min. Combination of AWASP with gas chromatog.-mass spectrometry and using pyridine-d5 as an internal standard allowed for developing the rapid, simple, and low-cost method for simultaneous quantification of UDMH transformation products with detection limits of 1-5 μg L-1 and linear concentration range covering 4 orders of magnitude. The method has been validated and successfully tested in the anal. of aqueous solutions of rocket fuel subjected to oxidation with atm. oxygen, as well as pyrolytic gasification in supercritical water modeling wastewater from carrier rockets launch sites. The experimental part of the paper was very detailed, including the reaction process of 1-Methylpyrazole(cas: 930-36-9Safety of 1-Methylpyrazole)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Safety of 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 930-36-9On May 31, 2019, Doba, Takahiro; Matsubara, Tatsuaki; Ilies, Laurean; Shang, Rui; Nakamura, Eiichi published an article in Nature Catalysis. The article was 《Homocoupling-free iron-catalyzed twofold C-H activation/cross-couplings of aromatics via transient connection of reactants》. The article mentions the following:

Herein, an efficient strategy was developed for the synthesis of biaryls and (aryl)alkenamides Ar(R)C=C(R1)C(O)NHAr1 [R = Me; R1 = Me; RR1 = (CH2)4; Ar = 3,4-Cl2C6H3, 5-Ph-2-thienyl, benzothiophen-2-yl, etc.; Ar1 = 8-quinolyl] via iron-catalyzed twofold C-H activation/cross-coupling of arenes with alkenyl/aryl carboxamides. A transient connection of two reactants by an anionic group appended to one reactant helped to achieve this goal under mildly oxidative iron-catalyzed conditions, through the formation of a productive heteroleptic R1-M-R2 intermediate. An N-(quinolin-8-yl)amide anion was utilized for the temporary connection and cross-coupled a stoichiometric mixture of aromatics in high yield without any trace of homocoupling products. A short-step synthesis of several donor/acceptor thiophene compounds and carbon/sulfur-bridged flat conjugated systems illustrated the utility of this method to streamline organic synthesis. After reading the article, we found that the author used 1-Methylpyrazole(cas: 930-36-9Application of 930-36-9)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Application of 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Palladium-catalyzed polyannulation of pyrazoles and diynes toward multifunctional poly(indazole)s under monomer non-stoichiometric conditions》 was published in Polymer Chemistry in 2019. These research results belong to Gao, Qingqing; Han, Ting; Qiu, Zijie; Zhang, Ruoyao; Zhang, Jun; Kwok, Ryan T. K.; Lam, Jacky W. Y.; Tang, Ben Zhong. Category: pyrazoles-derivatives The article mentions the following:

A new synthetic route toward multifunctional poly(indazole)s (PIs) with an effect of monomer stoichiometry imbalance-promoted polymerization is described in this work. The palladium-catalyzed oxidative polyannulations of internal diynes and 1-methylpyrazole proceed smoothly in 1,4-dioxane at 120°C with copper acetate monohydrate functioning as the oxidant. A series of PIs with high mol. weights (Mw up to 35 800) are generated in good yields (up to 84.0%) under monomer non-stoichiometric conditions. These polymers exhibit high thermal stability, losing merely 5% of their weights at high temperatures of 321-353°C. The solid thin films of these PIs show high and UV-tunable refractive indexes (n = 1.8870-1.6051) in a wide wavelength range of 400-900 nm. The tetraphenylethene-containing PI shows obvious solid-state emission properties and good photosensitivity. Its thin film was successfully fabricated into a well-defined two-dimensional fluorescent photopattern with sharp edges. The experimental part of the paper was very detailed, including the reaction process of 1-Methylpyrazole(cas: 930-36-9Category: pyrazoles-derivatives)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Product Details of 930-36-9On May 3, 2021 ,《Electrophotocatalytic C-H Azolation of Arenes》 appeared in ChemElectroChem. The author of the article were Hou, Zhong-Wei; Xu, Hai-Chao. The article conveys some information:

An electrophotocatalytic method was developed for the dehydrogenative cross coupling of arenes with azoles employing a bicatalytic system consisting of acridinium dye and (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO). The reactions were conducted in a simple undivided cell with visible-light irradiation and requires no external chem. oxidant. In addition to this study using 1-Methylpyrazole, there are many other studies that have used 1-Methylpyrazole(cas: 930-36-9Product Details of 930-36-9) was used in this study.

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Product Details of 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of C4H6N2OOn October 1, 2003 ,《New 1-substituted 4-cinnamoyl-5-hydroxypyrazoles and precursors thereof: Synthesis, ring closure reactions and NMR-spectroscopic investigations》 was published in Heterocycles. The article was written by Holzer, Wolfgang; Krca, Ingrid. The article contains the following contents:

Reaction of 1-substituted 5-hydroxy-1H-pyrazoles (pyrazolones) with trans-cinnamoyl chloride/calcium hydroxide in dioxane affords the corresponding 4-cinnamoyl-5-hydroxy-1H-pyrazoles. Cyclization of the latter into 5,6-dihydropyrano[2,3-c]pyrazol-4-ones proceeds in very low yields upon treatment with concentrated sulfuric acid. 1,6-Diphenyl-1H-pyrano[2,3-c]pyrazol-4-one was synthesized by reaction of 4-acetyl-5-hydroxy-1-phenyl-1H-pyrazole with benzoyl chloride and lithium bis(trimethylsilyl)amide and subsequent cyclization of the thus obtained 1,3-diketone. NMR-spectroscopic investigations with the obtained 4-substituted 5-hydroxypyrazoles and their precursors regarding their tautomeric behavior in various solvents are presented. The cyclocondensation of (2E)-1-[5-hydroxy-3-methyl-1-(phenylmethyl)-1H-pyrazol-4-yl]-3-phenyl-2-propen-1-one gave 3-methyl-6-phenyl-1-(phenylmethyl)-1H-pyrano[2,3-c]pyrazol-4-one, however in only 2% yield. In the experiment, the researchers used 2-Methyl-1H-pyrazol-3(2H)-one(cas: 3310-35-8Electric Literature of C4H6N2O)

2-Methyl-1H-pyrazol-3(2H)-one(cas: 3310-35-8) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Electric Literature of C4H6N2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Combination of experimental and theoretical methods to explore the amino-functionalized pyrazolium ionic liquids: An efficient single-component catalyst for chemical fixation of CO2 under mild conditions》 was written by Zhang, Jingshun; Zhu, Xinrui; Fan, Baowan; Guo, Jia; Ning, Pan; Ren, Tiegang; Wang, Li; Zhang, Jinglai. Recommanded Product: 930-36-9 And the article was included in Molecular Catalysis on April 30 ,2019. The article conveys some information:

Four new amino-functionalized pyrazolium ionic liquids, I [R = Me, Et; n = 1, 2] were firstly synthesized in simple reaction steps with cheap raw materials. Ionic liquids I would catalyze the coupling reaction of carbon dioxide with propyleneoxide under optimal reaction conditions, 110 °C, 1.5 MPa carbon dioxide initial pressure as well as 1.0 mol% catalyst amount for 4.0 h, with propylene carbonate yield over 94%. The reaction temperature was decreased by 10-20 °C as compared with other single-component ionic liquids and at the same time, carbon dioxide initial pressure was not increased to keep 1.5 MPa. The recyclability and suitability of amino-functionalized pyrazolium ionic liquids were explored and catalytic mechanism was investigated by d. functional theory. Moreover, the influence of weak interactions on reaction was analyzed by atoms in mols. and non-covalent interactions. As compared with other reported ionic liquids, the reaction condition catalyzed by ionic liquid I [R = Et, n = 2] was more benign with comparable product yield. More importantly, there was good balance among various reaction conditions without sacrificing one to ensure others. In addition to this study using 1-Methylpyrazole, there are many other studies that have used 1-Methylpyrazole(cas: 930-36-9Recommanded Product: 930-36-9) was used in this study.

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Recommanded Product: 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Yi, Rong-Nan; Wu, Zhi-Lin; Ouyang, Wen-Tao; Wang, Wei-Fan; He, Wei-Min published their research in Tetrahedron Letters on August 3 ,2021. The article was titled 《Green synthesis of 4-organylselanyl-1H-pyrazoles through electrochemical cross-dehydrogenative coupling of 1H-pyrazoles and diorganyl diselenides》.Formula: C4H6N2 The article contains the following contents:

An atom-economical and efficient method for synthesizing 4-organylselanyl-1H-pyrazoles through electrochem. cross-dehydrogenation coupling of N-unsubstituted pyrazoles with diorganyl diselenides under chem. oxidant-free and mild conditions was developed. This reaction not only shows good functional-group tolerance but also has high scalability. The experimental part of the paper was very detailed, including the reaction process of 1-Methylpyrazole(cas: 930-36-9Formula: C4H6N2)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Formula: C4H6N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

de Araujo, Marcos Lopes; Correia, Gilvan Aguiar; Carvalho, Wagner Alves; Shul’pina, Lidia Sergeevna; Kozlov, Yuriy Nikitovich; Shul’pin, Georgiy Borisovich; Mandelli, Dalmo published their research in Catalysis Today on December 1 ,2021. The article was titled 《The effect of additives (pyrazine, pyrazole and their derivatives) in the oxidation of 2-butanol with FeCl3-H2O2 in aqueous solutions》.Reference of 1-Methylpyrazole The article contains the following contents:

In the present paper we described the oxidation of 2-butanol as a representative of secondary aliphatic alcs. The oxidizing system FeCl3-H2O2 was used. A kinetic study of the oxidation reaction has been carried out. Different substituted pyrazines and pyrazoles, namely 2-pyrazinecarboxylic acid (PCA), 5-methyl-2-pyrazinecarboxylic acid (5MPCA), 2-methylpyrazine (2MPZINE), 3-(trifluoromethyl)pyrazole (3TFMPZOLE), 3-methylpyrazole (3MPZOLE) and 1-methylpyrazole (1MPZOLE) were added as cooperating ligands in aqueous solutions DFT based calculations were also used in order to evaluate the different results obtained. Addition of PCA, 5MPCA and 3TFMPZOLE led to a better reaction performance, while the other ligands led to lower accumulation of products than the reaction without additives. Performed DFT studies suggested that the metal-ligand π-backbonding might be responsible for the reaction activity increase, while ligands more strongly bonded to Fe make it more difficult the access to the metal, leading to lower yields. After reading the article, we found that the author used 1-Methylpyrazole(cas: 930-36-9Reference of 1-Methylpyrazole)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Reference of 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Category: pyrazoles-derivativesOn November 15, 2019 ,《Synthesis, physicochemical and antimicrobial properties of cardanol-derived quaternary ammonium compounds (QACs) with heterocyclic polar head》 appeared in Journal of Molecular Liquids. The author of the article were Ma, Jingyi; Liu, Na; Huang, Mengen; Wang, Limin; Han, Jianwei; Qian, Hui; Che, Fei. The article conveys some information:

As new biomass derived raw material, cardanol has attracted the attention of numerous academic and industrial groups due to its renewability and unique structural features. In this work, seven cardanol-derived quaternary ammonium compounds (QACs) were synthesized with their physicochem. properties and antimicrobial ability evaluated. The surface tension was measured in aqueous medium by the platinum ring method, 2b has the optimal surface activities, which is considerably better than commercialized QAC product cetyltrimethylammonium bromide. Both broth dilution method and agar dilution method were used to obtain the MIC and MBC values of the targeted QACs. 1a, 1b, 2b inhibit the tested bacterial at a concentration of 32μg/mL. SEM (SEM) results intuitively showed that the QACs could interact with the bacterial cell membrane, for disrupting the integrity of the membrane. Meanwhile, it was found that the antimicrobial activity depended not only on the alkyl chain length, but also on the CMC value. To sum, seven cardanol-derived QACs were synthesized easily, which showed excellent surface activities and antimicrobial activity, as a promising alternative to the existing fossil fuel derived cationic surfactants and antiseptics. The experimental part of the paper was very detailed, including the reaction process of 1-Methylpyrazole(cas: 930-36-9Category: pyrazoles-derivatives)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics