Application of 930-36-9On May 31, 2019, Doba, Takahiro; Matsubara, Tatsuaki; Ilies, Laurean; Shang, Rui; Nakamura, Eiichi published an article in Nature Catalysis. The article was 《Homocoupling-free iron-catalyzed twofold C-H activation/cross-couplings of aromatics via transient connection of reactants》. The article mentions the following:
Herein, an efficient strategy was developed for the synthesis of biaryls and (aryl)alkenamides Ar(R)C=C(R1)C(O)NHAr1 [R = Me; R1 = Me; RR1 = (CH2)4; Ar = 3,4-Cl2C6H3, 5-Ph-2-thienyl, benzothiophen-2-yl, etc.; Ar1 = 8-quinolyl] via iron-catalyzed twofold C-H activation/cross-coupling of arenes with alkenyl/aryl carboxamides. A transient connection of two reactants by an anionic group appended to one reactant helped to achieve this goal under mildly oxidative iron-catalyzed conditions, through the formation of a productive heteroleptic R1-M-R2 intermediate. An N-(quinolin-8-yl)amide anion was utilized for the temporary connection and cross-coupled a stoichiometric mixture of aromatics in high yield without any trace of homocoupling products. A short-step synthesis of several donor/acceptor thiophene compounds and carbon/sulfur-bridged flat conjugated systems illustrated the utility of this method to streamline organic synthesis. After reading the article, we found that the author used 1-Methylpyrazole(cas: 930-36-9Application of 930-36-9)
1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Application of 930-36-9
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics