pyrazoles-derivatives

In 2019,Chemical Science included an article by Chong, Eugene; Qu, Bo; Zhang, Yongda; Cannone, Zachary P.; Leung, Joyce C.; Tcyrulnikov, Sergei; Nguyen, Khoa D.; Haddad, Nizar; Biswas, Soumik; Hou, Xiaowen; Kaczanowska, Katarzyna; Chwalba, Michal; Tracz, Andrzej; Czarnocki, Stefan; Song, Jinhua J.; Kozlowski, Marisa C.; Senanayake, Chris H.. Application In Synthesis of 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. The article was titled 《A versatile catalyst system for enantioselective synthesis of 2-substituted 1,4-benzodioxanes》. The information in the text is summarized as follows:

The synthesis of enantiomerically enriched 1,4-benzodioxanes containing alkyl, aryl, heteroaryl and/or carbonyl substituents at the 2-position was reported. The starting 1,4-benzodioxines were readily synthesized via ring closing metathesis using an efficient nitro-Grela catalyst at ppm levels. Excellent enantioselectivities of up to 99:1 er were obtained by using the versatile catalyst system [Ir(cod)Cl]2/BIDIME-dimer in the asym. hydrogenation of 2-substituted 1,4-benzodioxines. Furthermore, DFT calculations revealed that the selectivity of the process was controlled by the protonation step; and coordinating groups on the substrate may alter the interaction with the catalyst, resulting in a change in the facial selectivity. In the experiment, the researchers used many compounds, for example, 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0Application In Synthesis of 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole)

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Application In Synthesis of 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Formula: C5H6N2O2In 1985 ,《N,N’-Linked biazoles. Part 5. Synthesis of pyrazolyl dimers by the reaction of 3-methoxycarbonyl-2-pyrazoline with lead tetraacetate》 appeared in Heterocycles. The author of the article were De Mendoza, Javier; Rosario Gonzalez-Muniz, M.; Rosario Martin, M.. The article conveys some information:

Depending on the reaction conditions, the title oxidation gave all products earlier reported and several new ones, e.g. I-III. In the experiment, the researchers used Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Formula: C5H6N2O2)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Formula: C5H6N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 1973,Akrem, A. A.; Kvasyuk, E. I.; Mikhailopulo, I. A. published 《Unusual reaction of 3-(methoxycarbonyl)-Δ2-pyrazoline with lead tetraacetate》.Tetrahedron Letters published the findings.Name: Methyl 1H-pyrazole-3-carboxylate The information in the text is summarized as follows:

The title reaction gave 70% 3-(methoxycarbonyl)-1-[1-(methoxycarbonyl)-cyclopropyl]pyrazole (I) and 14% 3-(methoxycarbonyl)-1-[3-(methoxycarbonyl)pyrazol-1-yl]-2-pyrazoline (II). NMR, ir, and uv spectral data for I, II, 3-(methoxycarbonyl)pyrazole, and 7-acetyl-3-(methoxycarbonyl)-2-pyrazoline were determined The experimental process involved the reaction of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Name: Methyl 1H-pyrazole-3-carboxylate)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Name: Methyl 1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2015,Cheema, Hammad; Islam, Ashraful; Han, Liyuan; El-Shafei, Ahmed published 《Monodentate pyrazole as a replacement of labile NCS for Ru (II) photosensitizers: Minimum electron injection free energy for dye-sensitized solar cells》.Dyes and Pigments published the findings.Computed Properties of C4H3F3N2 The information in the text is summarized as follows:

A mono-dentate ligand of 3-(trifluoromethyl) pyrazole, instead of the labile isothiocyanate ligand for Ru (II) photosensitizers, was developed. This mol. modulation resulted in a new structure motif (HD-11) with 50 nm red shift in the low energy metal-to-ligand charge transfer (MLCT) absorption peak. However, electrochem. measurements revealed that both ground and excited state oxidation potentials were stabilized, this is attributed to the presence of strong electron withdrawing group CF3 tethered to pyrazole, which resulted in more free energy for dye regeneration, but less driving force for electron injection into the conduction band of TiO2. Hence HD-11, resulted in lower Jsc of 12.89 mA cm-2 compared to 17.07 mA cm-2 of N719 under similar conditions. Addnl., Voc of HD-11 was lower than N719, owing to decreased eTiO2 life time of 0.674 ms compared to 8.8 ms of N719 for injected electrons as found by impedance measurements. In addition to this study using 3-(Trifluoromethyl)-1H-pyrazole, there are many other studies that have used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Computed Properties of C4H3F3N2) was used in this study.

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Computed Properties of C4H3F3N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Formula: C4H3F3N2In 2020 ,《Pyrazole-Enaminones as Promising Prototypes for the Development of Analgesic Drugs》 appeared in ChemistrySelect. The author of the article were Moraes, Paulo A.; Brum, Evelyne S.; Brusco, Indiara; Marangoni, Mario A.; Lobo, Marcio M.; Camargo, Adriano F.; Nogara, Pablo A.; Bonacorso, Helio G.; Martins, Marcos A. P.; Da Rocha, Joao Batista T.; Oliveira, Sara M.; Zanatta, Nilo. The article conveys some information:

This study reports the chemo- and regioselective synthesis, at good yields, of (E)-4-(amino)-1,1,1-trifluoro-5-(4,5-alkyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)pent-3-en-2-ones (pyrazole-enaminones), from the of N-alkylation reaction of trifluoromethyl pyrazoles with 5-bromo enaminones. The obtained compounds were tested as potential analgesics in a screening test involving mice. Three of these compounds significantly reduced the spontaneous nociception induced by the application of capsaicin, which is an algogenic substance. Compound I presented satisfactory antinociceptive activity compared to celecoxib, a drug used as a pos. control, without promoting locomotor changes in the mice. Moreover, mol. modeling simulations showed that compound I interacts with the cyclooxygenase enzyme at the same binding site as celecoxib. Together, present data suggest that compound I is a promising prototype for the development of new analgesic drugs. After reading the article, we found that the author used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Formula: C4H3F3N2)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Formula: C4H3F3N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Name: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleIn 2018 ,《A robust iron catalyst for the selective hydrogenation of substituted (iso)quinolones》 was published in Chemical Science. The article was written by Sahoo, Basudev; Kreyenschulte, Carsten; Agostini, Giovanni; Lund, Henrik; Bachmann, Stephan; Scalone, Michelangelo; Junge, Kathrin; Beller, Matthias. The article contains the following contents:

By applying N-doped carbon modified iron-based catalysts, the controlled hydrogenation of N-heteroarenes, especially (iso)quinolines, is achieved. The catalysts are prepared by pyrolysis of a carbon-impregnated composite, obtained from iron(II) acetate and N-aryliminopyridines. As demonstrated by TEM, XRD, XPS and Raman spectroscopy, the synthesized material is composed of Fe(0), Fe3C and FeNx in a N-doped carbon matrix. The decent catalytic activity of this robust and easily recyclable Fe-material allowed for the selective hydrogenation of various (iso)quinoline derivatives, even in the presence of reducible functional groups, such as nitriles, halogens, esters and amides. For a proof-of-concept, this nanostructured catalyst was implemented in the multistep synthesis of natural products and pharmaceutical lead compounds as well as modification of photoluminescent materials. As such this methodol. constitutes the first heterogeneous iron-catalyzed hydrogenation of substituted (iso)quinolines with synthetic importance. After reading the article, we found that the author used 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0Name: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole)

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. Name: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 1967,Micheel, Fritz; Dammert, Walter published 《Condensation products from trimethyl fluorotrimesate and α-amino-β-hydroxy compounds》.Chemische Berichte published the findings.Related Products of 15366-34-4 The information in the text is summarized as follows:

N-[6-carboxy-2,4-bis(methoxycarbonyl)phenyl]-DL-serinolactone (I) was treated with CH2N2 to form a pyrazoline which was converted to the corresponding cyclopropane derivative by elimination of N. The structures of the pyrazoline and cyclopropane derivatives were confirmed by degradation and synthesis. Condensates of DL-threonine and β-phenyl-DL-serine with methyl fluorotrimesate formed ester lactones, which on treatment with CH2N2 formed Me N-[2,4,6-(trimethoxycarbonyl)phenyl]-α-aminocrotonate and Me N-[2,4,6 (trimethoxycarbonyl)phenyl]-α-aminocinnamate, resp. In the experimental materials used by the author, we found Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Related Products of 15366-34-4)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Related Products of 15366-34-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2011,Qiao, Jennifer X.; Wang, Tammy C.; Hu, Carol; Li, Jianqing; Wexler, Ruth R.; Lam, Patrick Y. S. published 《Transformation of Anionically Activated Trifluoromethyl Groups to Heterocycles under Mild Aqueous Conditions》.Organic Letters published the findings.Reference of 3-(Trifluoromethyl)-1H-pyrazole The information in the text is summarized as follows:

The (hetero)aromatic trifluoromethyl group is present in many biol. active mols. and is generally considered to be chem. stable. In this paper, a convenient one-step synthesis of C-C linked aryl-heterocycles or heteroaryl-heterocycles in good to excellent yields via the reaction of anionically activated trifluoromethyl groups with amino nucleophiles containing a second NH, OH, or SH nucleophile in 1 N sodium hydroxide is reported. The method has high functional group tolerability and is potentially useful in parallel synthesis. After reading the article, we found that the author used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Reference of 3-(Trifluoromethyl)-1H-pyrazole)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Reference of 3-(Trifluoromethyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2014,Anderson, Erin D.; Duerfeldt, Adam S.; Zhu, Kaicheng; Glinkerman, Christopher M.; Boger, Dale L. published 《Cycloadditions of Noncomplementary Substituted 1,2,3-Triazines》.Organic Letters published the findings.Synthetic Route of C5H6N2O2 The information in the text is summarized as follows:

The scope of the [4 + 2] cycloaddition reactions of substituted 1,2,3-triazines, bearing noncomplementary substitution with electron-withdrawing groups at C4 and/or C6, is described. The studies define key electronic and steric effects of substituents impacting the reactivity, mode (C4/N1 vs C5/N2), and regioselectivity of the cycloaddition reactions of 1,2,3-triazines with amidines, enamines, and ynamines, providing access to highly functionalized heterocycles [e.g., Me 1,2,3-triazine-4-carboxylate + benzamidine → Me 2-phenylpyrimidine-4-carboxylate (71%)].Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Synthetic Route of C5H6N2O2) was used in this study.

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Synthetic Route of C5H6N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pei, Congcong; Chen, Xiaoyu; Li, Linlin; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng published their research in Tetrahedron Letters in 2021. The article was titled 《Copper-catalyzed C3-amination of quinoxalin-2(1H)-ones: Using Selectfluor as a mild oxidant》.Application In Synthesis of 3-(Trifluoromethyl)-1H-pyrazole The article contains the following contents:

A practical and efficient route for copper-catalyzed C-3 amination of quinoxalin-2(1H)-ones with easily available azoles as nitrogen sources and Selectfluor as mild oxidant was developed. The transformation featured at. economy, simple operation, broad substrate scope, and moderate to excellent yields. After reading the article, we found that the author used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Application In Synthesis of 3-(Trifluoromethyl)-1H-pyrazole)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Application In Synthesis of 3-(Trifluoromethyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics