Tag: 100-200

Cyanoethylhydrazide in the preparation of nitrogen heterocycles. III. Heterocyclic 7-rings through the reaction of 1,3-dicarbonyl compounds with cyanoacetylhydrazide was written by Ried, W.;Kocher, E. U.. And the article was included in Angewandte Chemie in 1958.Electric Literature of C6H9N3O This article mentions the following:

Acetylacetone with cyanoacetylhydrazide in alc. in the presence of a few drops AcOH gives the mono(cyanoacetylhydrazone) (I), m. 165-6°, very soluble in dilute NaOH. The addition of at least 2 moles aqueous NaOH solution to I followed by acidification of the resulting yellow solution with AcOH yields MeC:C(CN).C(OH):N.N:CMe.CH₂ (or ketone) (II), yellow, m. 237-8°, very soluble in dilute NaOH, soluble in dilute HCl. With HNO₂, II gives orange leaves, m. 183-4°. In the same way, benzoylacetone and cyanoacetylhydrazide give PhCOCH₂CMe:NNHCOCH₂CN, (III), m. 122-3° soluble in dilute NaOH. 1-Cyanoacetyl-3-methyl-5-phenylpyrazole, m. 153-4°, may be prepared by treating III with aqueous alc. HCl. III with base yields PhC:C(CN).C(OH):N.N.CMe.CH₂ (or ketone), light yellow needles, m. 257-8° soluble in dilute NaOH and dilute HCl, gives red needles, m. 216-17°, with HNO₂. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Electric Literature of C6H9N3O).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Electric Literature of C6H9N3O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Conventional, grinding and microwave-assisted synthesis, biological evaluation of some novel pyrazole and pyrazolone derivatives was written by Naguib, H. M.;Shaban, S. N.;Abdelghaffar, N. F.;Dauoud, N. T.;Sayed, G. H.;Anwer, K. E.. And the article was included in Journal of Basic and Environmental Sciences in 2021.Application of 51395-52-9 This article mentions the following:

Under conventional, grinding and microwave methods, reaction of 3-methyl-1H-pyrazol-5-one with benzene diazonium chloride, 4-carboxybenzenediazonium chloride and nitrous acid furnished the diazenyl derivatives resp. Reaction of 4-((3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)diazenyl)benzoic acid with salicyladehyde and 4-(chlorodiazenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one with malononitrile followed by hydrazine hydrate afforded pyrazolones resp. 3-Methyl-1H-pyrazol-5-one was converted to 4-bromopyrazolone, which when allowed to react with urea, thiourea, o-phenylenediamine, 2-amino-3-hydroxypyridine and 2-amino-5-methylphenyl furnished 4-aminopyrazolones, resp. While its reaction with p-phenylenediamine in 1:2 ratio gave bis-pyrazole derivative Also, the reaction of 3-methyl-1H-pyrazol-5-one toward thiosemicarbazide, thiourea, urea and guanidine hydrochloride gave the pyrazole derivatives, resp. The reaction of 1-(5-methyl-4H-pyrazol-3-yl)thiourea with benzaldehyde gave Schiff base, while its reaction with Et chloroacetate gave the thioxoimidazolidinone derivative, which on reaction with thiosemicarbazide afforded imidazotriazolothione derivative Also, the reactivity of pyrazole reacted with salicyladehyde and o-chlorobenzaldehyde was investigated to afford the corresponding Schiff base, resp. These new scaffolds were screened for in vitro antimicrobial and cytotoxic activities. Most analogs revealed excellent to good results. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Application of 51395-52-9).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Application of 51395-52-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Comparative Studies of Cathodically-Promoted and Base-Catalyzed Michael Addition Reactions of Levoglucosenone was written by Samet, Alexander V.;Niyazymbetov, Murat E.;Semenov, Victor V.;Laikhter, Andrei L.;Evans, Dennis H.. And the article was included in Journal of Organic Chemistry in 1996.Product Details of 5334-39-4 This article mentions the following:

Regioselective Michael addition of nitro and heterocyclic compounds to levoglucosenone, is effectively catalyzed by amines and also by cathodic electrolysis. In comparison to the base-catalyzed reaction, it was found that under electrochem. conditions the reaction proceeds under milder conditions and with higher yields. Cathodically-initiated Michael addition of thiols to levoglucosenone using small currents produces the previously unknown threo addition product in several instances. The normal erythro isomer, identified as the kinetic product, tends to be formed when large currents are used. In contrast, slow, low current electrolysis promote equilibration of the two forms so that erythro can be converted to threo by the retro reaction and readdn. Addition of 2-naphthalenethiol to (R)-(+)-apoverbenone is also reported. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4Product Details of 5334-39-4).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Product Details of 5334-39-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Solvatochromism of Heteroaromatic Compounds: XIX. Factors Affecting Quantitative Characteristics of Solvatochromism in Aprotic Inert Media was written by Turchaninov, V. K.;Vokin, A. I.;Aksamentova, T. N.;Krivoruchka, I. G.;Shulunova, A. M.;Andriyankova, L. V.. And the article was included in Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) in 2003.COA of Formula: C4H5N3O2 This article mentions the following:

The effects of aprotic inert media on the electronic absorption spectra of aromatic nitro compounds p-NO₂C₆H₄R were used as evidence for the linear correlation between the slope s_a of the solvatochromism equations ν_max = ν₀ + s_aπ^* and the dipole moments of the mols. in their ground electronic state μ_g. A linear correlation was established between ν₀ and the first ionization potential of subunits PhR. A new approach to estimating the dipole moment of electronically excited mols. (μ_e) for mols. like p-NO₂C₆H₄R from the correlation μ_e = rμ_g was proposed. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1COA of Formula: C4H5N3O2).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. COA of Formula: C4H5N3O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Orientation of the alkylation reaction of pyrazoles under neutral conditions and in phase-transfer catalysis was written by Tarrago, Georges;Ramdani, Abdelkrim;Elguero, Jose;Espada, Modesta. And the article was included in Journal of Heterocyclic Chemistry in 1980.Application of 19959-77-4 This article mentions the following:

The N-butylation and N-benzylation of nine pyrazoles bearing different substituents in positions 3 and 5 have been studied in neutral and basic medium (phase transfer catalysis). The orientation of the reaction depends strongly on the method used when the position 3 (or 5) of the starting pyrazole bears a substituent with a lone pair in the ortho position (pyrazolyl or pyridyl). In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Application of 19959-77-4).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Application of 19959-77-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

IR-spectroscopic study of the structure of indazoles, pyrazolo[3,4-b]pyridines, and pyrazolo[3,4-b]pyrazine was written by Sennitskaya, L. V.;Timoshenkova, Yu. D.;Kikot, B. S.;Pentin, Yu. A.;Blanko, F. F.;Korbukh, I. A.;Preobrazhenskaya, M. N.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1977.Product Details of 63725-52-0 This article mentions the following:

The IR of I (R = H, Me), II, III (R = H, NH2, Me2N), IV, V (R, R1 = H, Me), and VI were discussed. A band at 2500-3300 cm-1, shifted to 2000-2400 cm-1 by deuteration, indicated that intermol. H bonding occurred in the crystals of the NH compounds The IR also indicated that protonation of III (R = NH2) occurred on one of the ring N atoms. In the experiment, the researchers used many compounds, for example, 6-Chloro-1-methylpyrazolo[5,4-b]pyridine (cas: 63725-52-0Product Details of 63725-52-0).

6-Chloro-1-methylpyrazolo[5,4-b]pyridine (cas: 63725-52-0) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Product Details of 63725-52-0

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis and Muscarinic Activities of 3-(Pyrazolyl)-1,2,5,6-tetrahydropyridine Derivatives was written by Plate, Ralf;Plaum, Marc J. M.;de Boer, Thijs;Andrews, John S.;Rae, Duncan R.;Gibson, Sam. And the article was included in Bioorganic & Medicinal Chemistry in 1996.Electric Literature of C8H7N3 This article mentions the following:

A series of 3-(pyrazolyl)-1,2,5,6-tetrahydropyridine derivatives was synthesized and tested for muscarinic activity in receptor binding assays using [³H]-oxotremorine-M (³H-OXO-M) and [³H]-pirenzepine (³H-PZ) as ligands. Example compounds are the (pyrazolyl)tetrahydropyridines I (R¹,R² = H, halo). Potential muscarinic agonistic or antagonistic properties of the compounds were determined using binding studies measuring their potencies to inhibit the binding of ³H-OXO-M and ³H-PZ. Preferential inhibition of ³H-OXO-M binding was used as an indicator for potential muscarinic agonistic properties: this potential was confirmed in functional studies on isolated organs. All compounds with agonistic properties showed ³H-PZ³H-OXO-M potency ratios in excess of 20. In contrast, for antagonists this ratio was found to be close to unity. Mono-halogenation resulted in compounds with M₃ agonistic properties as shown by their atropine sensitive stimulant properties in the guinea pig ileum, but with very little or no M₁ activity. Some minor in vivo effects were observed for these compounds One compound also showed pos. mnemonic properties in rats where spatial short-term memory had been compromised by temporary cholinergic depletion. These data indicate that some M₃ agonism may be desired in therapeutic agents aimed at the treatment of the cognitive deficits of Alzheimer’s disease patients. In the experiment, the researchers used many compounds, for example, 3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9Electric Literature of C8H7N3).

3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Electric Literature of C8H7N3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Nitrogeneous five-membered heterocycles. Some pyrazole derivatives with possible hypoglycemic action was written by Cojocaru, Zenaida;Bicleseanu, Cornelia. And the article was included in Revista Medicala (Tirgu-Mures, Romania) in 1971.Electric Literature of C6H9N3O This article mentions the following:

-Acyl-3,5-dimethylpyrazoles (I) were prepared Their phys.-chem. constants were given. The ir spectrum of I showed a carbonyl absorption at 1700-1760 cm-1. The hypoglycemic action of 3,5-dimethylpyrazole and 1-carbamoyl-3,5-dimethyl-pyrazole (I, R = NH2) was compared in rats with that of insulin, sulfamylurea, and biguanidine. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Electric Literature of C6H9N3O).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Electric Literature of C6H9N3O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Facile synthesis of annelated NADH model precursors was written by Benoit, R.;Dupas, G.;Bourguignon, J.;Queguiner, G.. And the article was included in Synthesis in 1987.Category: pyrazoles-derivatives This article mentions the following:

Cyclization of (MeO)₂CHC(CN):CHONa I with amino derivatives of electron donating heterocycles II gave 49-85% title compounds III. E.g., the reaction of I with IV gave 49% V. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Category: pyrazoles-derivatives).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Evolution of S/N containing compounds in pyrolysis of highly oily petroleum sludge was written by Wang, Ziyi;Wang, Zhenbo;Sun, Zhiqian;Ma, Kesheng;Du, Lianmeng;Yuan, Rui. And the article was included in Fuel in 2022.Recommanded Product: 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine This article mentions the following:

Pyrolysis of oily sludge in inert environment has a strong potential for energy recovery, in which the transformation of S/N containing compounds is a key to influence the quality of various products. This work addresses the evolution of S/N containing compounds in pyrolysis process of two oily sludge samples with high oil content by comparing the species and distribution of S/N containing compounds in origin samples and char. The results demonstrate that aromatic and saturated completed volatilize or react completely at 500 °C while the resin completed the reaction at 750 °C-800 °C. The S-containing compounds are mainly Sulfate-S. At 500 °C, most sulfate remained unchanged, and continued heating led to a large-scale decomposition After condensation and cyclization, the S/N compounds were transformed into components with high thermal stability. Sulfoxide-S, Thiophenic-S and Aromatic-S with more stable thermal stability held the main position at higher temperature The transformation of N-containing compounds was almost based on Proteins-N. As the temperature rising from 500 °C to 700 °C and 900 °C, the content of protein-N decreased continuously and transformed into high thermal stability Pyridine-N, Pyrrole-N and Quaternary graphic-N, which could account for more than 90%. This work provides a theor. basis for the distribution and transformation of S/N in char, the deep application of char and the pollution prevention in subsequent treatment. In the experiment, the researchers used many compounds, for example, 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2Recommanded Product: 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine).

1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Recommanded Product: 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics