Nitrogeneous five-membered heterocycles. Some pyrazole derivatives with possible hypoglycemic action was written by Cojocaru, Zenaida;Bicleseanu, Cornelia. And the article was included in Revista Medicala (Tirgu-Mures, Romania) in 1971.Electric Literature of C6H9N3O This article mentions the following:
-Acyl-3,5-dimethylpyrazoles (I) were prepared Their phys.-chem. constants were given. The ir spectrum of I showed a carbonyl absorption at 1700-1760 cm-1. The hypoglycemic action of 3,5-dimethylpyrazole and 1-carbamoyl-3,5-dimethyl-pyrazole (I, R = NH2) was compared in rats with that of insulin, sulfamylurea, and biguanidine. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Electric Literature of C6H9N3O).
3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Electric Literature of C6H9N3O
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics