pyrazoles-derivatives

HPLC of Formula: 20154-03-4In 2010 ,《Lewis Acid Catalyzed Synthesis of Poly(pyrazolyl)borate Ligands》 appeared in Organometallics. The author of the article were Chen, Changle; Jordan, Richard F.. The article conveys some information:

Lewis acids catalyze the reaction of Li[MeBH3] and Na[BH4] with pyrazoles to yield poly(pyrazolyl)borates under mild conditions. The reaction of Li[MeBH3] with 2 equiv of 3-mesitylpyrazole (HpzMs) at 23° (2 days) affords Li[MeB(3-mesityl-pz)2H] (Li[MeBpMs]) and Li[MeB(3-mesityl-pz)(5-mesityl-pz)H] (Li[MeBpMs*]) in 88% yield (3:1 isomer ratio) in the presence of MeB(OiPr)2 (5 mol % vs. HpzMs) but only 28% yield without this additive. Similar enhancements in the yield of Li[MeBpR] products are observed in the reaction of Li[MeBH3] with 3-tBu-pyrazole, 3,5-Me2-pyrazole (Hpz*), and 3,5-tBu2-pyrazole. The kinetics of the MeB(OiPr)2-catalyzed and uncatalyzed reaction of Li[MeB(3-mesityl-pz)H2]/Li[MeB(5-mesityl-pz)H2] with HpzMs were compared assuming that Li[MeB(3-mesityl-pz)H2] and Li[MeB(5-mesityl-pz)H2] react at the same rate. The estimated second-order rate constants are k(catalyzed) = 1.0 × 10-4 M-1 s-1 and k(uncatalyzed) = 2.1 × 10-5 M-1 s-1 at 23° in THF. The reaction of Li[MeBH3] with 3 equiv of HpzMs (THF, 60°, 2 days) in the presence of 3 mol % MeB(OiPr)2 affords Li[MeB(3-mesityl-pz)3] (75% yield), but only Li[MeBpMs] and Li[MeBpMs*] without this additive. Similar results were observed for the reaction of Li[MeBH3] with 3-CF3-pyrazole. The reaction of Na[BH4] and 3 equiv of Hpz* (THF, 60°, 4 h) gave Na[B(3,5-Me2-pz)2H2] in 93% yield in the presence of BF3·Et2O (5 mol % vs. Hpz*) but only 5% without this additive. Coordination of the pyrazole to the Lewis acid is expected to decrease the pKa of the pyrazole and increase the rate of B-H bond protonolysis. After reading the article, we found that the author used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4HPLC of Formula: 20154-03-4)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.HPLC of Formula: 20154-03-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Palladium-catalyzed polyannulation of pyrazoles and diynes toward multifunctional poly(indazole)s under monomer non-stoichiometric conditions》 was published in Polymer Chemistry in 2019. These research results belong to Gao, Qingqing; Han, Ting; Qiu, Zijie; Zhang, Ruoyao; Zhang, Jun; Kwok, Ryan T. K.; Lam, Jacky W. Y.; Tang, Ben Zhong. Category: pyrazoles-derivatives The article mentions the following:

A new synthetic route toward multifunctional poly(indazole)s (PIs) with an effect of monomer stoichiometry imbalance-promoted polymerization is described in this work. The palladium-catalyzed oxidative polyannulations of internal diynes and 1-methylpyrazole proceed smoothly in 1,4-dioxane at 120°C with copper acetate monohydrate functioning as the oxidant. A series of PIs with high mol. weights (Mw up to 35 800) are generated in good yields (up to 84.0%) under monomer non-stoichiometric conditions. These polymers exhibit high thermal stability, losing merely 5% of their weights at high temperatures of 321-353°C. The solid thin films of these PIs show high and UV-tunable refractive indexes (n = 1.8870-1.6051) in a wide wavelength range of 400-900 nm. The tetraphenylethene-containing PI shows obvious solid-state emission properties and good photosensitivity. Its thin film was successfully fabricated into a well-defined two-dimensional fluorescent photopattern with sharp edges. The experimental part of the paper was very detailed, including the reaction process of 1-Methylpyrazole(cas: 930-36-9Category: pyrazoles-derivatives)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 930-36-9On May 31, 2019, Doba, Takahiro; Matsubara, Tatsuaki; Ilies, Laurean; Shang, Rui; Nakamura, Eiichi published an article in Nature Catalysis. The article was 《Homocoupling-free iron-catalyzed twofold C-H activation/cross-couplings of aromatics via transient connection of reactants》. The article mentions the following:

Herein, an efficient strategy was developed for the synthesis of biaryls and (aryl)alkenamides Ar(R)C=C(R1)C(O)NHAr1 [R = Me; R1 = Me; RR1 = (CH2)4; Ar = 3,4-Cl2C6H3, 5-Ph-2-thienyl, benzothiophen-2-yl, etc.; Ar1 = 8-quinolyl] via iron-catalyzed twofold C-H activation/cross-coupling of arenes with alkenyl/aryl carboxamides. A transient connection of two reactants by an anionic group appended to one reactant helped to achieve this goal under mildly oxidative iron-catalyzed conditions, through the formation of a productive heteroleptic R1-M-R2 intermediate. An N-(quinolin-8-yl)amide anion was utilized for the temporary connection and cross-coupled a stoichiometric mixture of aromatics in high yield without any trace of homocoupling products. A short-step synthesis of several donor/acceptor thiophene compounds and carbon/sulfur-bridged flat conjugated systems illustrated the utility of this method to streamline organic synthesis. After reading the article, we found that the author used 1-Methylpyrazole(cas: 930-36-9Application of 930-36-9)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Application of 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The author of 《Acid Catalyzed N-Alkylation of Pyrazoles with Trichloroacetimidates》 were Meador, Rowan I. L.; Mate, Nilamber A.; Chisholm, John D.. And the article was published in Organics in 2022. Safety of 4-(4-Nitrophenyl)-1H-pyrazole The author mentioned the following in the article:

A new method for the N-alkylation of pyrazoles has been developed using trichloroacetimidate electrophiles C(Cl)3C=(NH)OR1 (R1 = 1-phenylethyl, 1-(naphthalen-2-yl)ethyl, benzyl, 2H-1,3-benzodioxol-5-yl(phenyl)methyl, etc.) and a Bronsted acid catalyst. These reactions provide ready access to N-alkyl pyrazoles, e.g., I, which are present in a variety of medicinally relevant lead structures. Benzylic, phenethyl and benzhydryl trichloroacetimidates provide good yields of the N-alkyl pyrazole products. Unsym. pyrazoles provide a mixture of the two possible regioisomers, with the major product being controlled by sterics. This methodol. provides an alternative to other alkylation methods that require strong base or high temperature In addition to this study using 4-(4-Nitrophenyl)-1H-pyrazole, there are many other studies that have used 4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9Safety of 4-(4-Nitrophenyl)-1H-pyrazole) was used in this study.

4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Safety of 4-(4-Nitrophenyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2014,Sharp, Phillip P.; Garnier, Jean-Marc; Huang, David C. S.; Burns, Christopher J. published 《Evaluation of functional groups as acetyl-lysine mimetics for BET bromodomain inhibition》.MedChemComm published the findings.Related Products of 847818-74-0 The information in the text is summarized as follows:

The ability of various functional groups to engage the acetyl-lysine (KAc) binding site within bromo- and extra-terminal domain (BET) protein family members BRD2, BRD3 and BRD4 was evaluated by screening small mol. fragments – coupled to a known arylsulfonamide scaffold – in biochem. inhibition assays. Useful structure activity relationships have been established and novel functional groups that bind to the KAc binding pocket identified. Addnl. microsomal degradation studies were also undertaken revealing significant differences in metabolic stability between two commonly employed BET inhibitor fragments. In addition to this study using 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, there are many other studies that have used 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0Related Products of 847818-74-0) was used in this study.

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities. Related Products of 847818-74-0

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2016,Zhang, Jin; Jia, Run-Ping; Wang, Dong-Hui published 《Copper-catalyzed C-N cross-coupling of arylboronic acids with N-acylpyrazoles》.Tetrahedron Letters published the findings.Category: pyrazoles-derivatives The information in the text is summarized as follows:

A copper-catalyzed C-N bond forming reaction of arylboronic acids and N-acylpyrazoles was developed. This procedure used N-acetyl protected pyrazoles as starting material instead of free pyrazoles (NH). The reaction worked under neutral conditions and did not require any base or ligand. The reaction showed good functional group tolerance. In addition to this study using 3-(Trifluoromethyl)-1H-pyrazole, there are many other studies that have used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Category: pyrazoles-derivatives) was used in this study.

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Tanwar, Lalita; Boergel, Jonas; Lehmann, Johannes; Ritter, Tobias published their research in Organic Letters in 2021. The article was titled 《Selective C-H Iodination of (Hetero)arenes》.SDS of cas: 15366-34-4 The article contains the following contents:

A strategy for selective C-H iodination of (hetero)arenes was decribed with a broad functional group tolerance. The utility and differentiation to other iodination methods of supposed sulfonyl hypoiodites for a set of carboarenes and heteroarenes was described.Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4SDS of cas: 15366-34-4) was used in this study.

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.SDS of cas: 15366-34-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Recommanded Product: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleIn 2017 ,《Stereoselective Photoredox-Catalyzed Chlorotrifluoromethylation of Alkynes: Synthesis of Tetrasubstituted Alkenes》 was published in Organic Letters. The article was written by Han, Hong Sik; Lee, Young Jin; Jung, Young-Sik; Han, Soo Bong. The article contains the following contents:

In the presence of fac-Ir(ppy)3 and Li2CO3 in acetone, trifluoromethanesulfonyl chloride added regioselectively and diastereoselectively to aryl alkynes such as 4-MeCONHC6H4CCMe under blue LED light to yield tetrasubstituted aryl trifluoromethyl alkenes such as I (R = Cl) in 34-85% yields and in all but one case as single diastereomers. I (R = Cl) underwent Suzuki coupling with aryl boronic acids or pinacolboronates to yield tetrasubstituted alkenes I (R = 4-EtOC6H4, 1-methyl-5-pyrazolyl, 3-furanyl, 2-benzothienyl) in 71-90% yields. The structure of a (tosylaminophenyl)chlorotrifluorobutene was determined by X-ray crystallog. The experimental part of the paper was very detailed, including the reaction process of 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0Recommanded Product: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole)

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. Recommanded Product: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Yi, Rong-Nan; Wu, Zhi-Lin; Ouyang, Wen-Tao; Wang, Wei-Fan; He, Wei-Min published their research in Tetrahedron Letters on August 3 ,2021. The article was titled 《Green synthesis of 4-organylselanyl-1H-pyrazoles through electrochemical cross-dehydrogenative coupling of 1H-pyrazoles and diorganyl diselenides》.Formula: C4H6N2 The article contains the following contents:

An atom-economical and efficient method for synthesizing 4-organylselanyl-1H-pyrazoles through electrochem. cross-dehydrogenation coupling of N-unsubstituted pyrazoles with diorganyl diselenides under chem. oxidant-free and mild conditions was developed. This reaction not only shows good functional-group tolerance but also has high scalability. The experimental part of the paper was very detailed, including the reaction process of 1-Methylpyrazole(cas: 930-36-9Formula: C4H6N2)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Formula: C4H6N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2018,ACS Catalysis included an article by Boit, Timothy B.; Weires, Nicholas A.; Kim, Junyong; Garg, Neil K.. Recommanded Product: 847818-74-0. The article was titled 《Nickel-Catalyzed Suzuki-Miyaura Coupling of Aliphatic Amides》. The information in the text is summarized as follows:

Authors report the Ni-catalyzed Suzuki-Miyaura coupling of aliphatic amide derivatives Prior studies have shown that aliphatic amide derivatives can undergo Ni-catalyzed carbon-heteroatom bond formation but that Ni-mediated C-C bond formation using aliphatic amide derivatives has remained difficult. The coupling disclosed herein is tolerant of considerable variation with respect to both the amide-based substrate and the boronate coupling partner and proceeds in the presence of heterocycles and epimerizable stereocenters. Moreover, a gram-scale Suzuki-Miyaura coupling/Fischer indolization sequence demonstrates the ease with which unique polyheterocyclic scaffolds can be constructed, particularly by taking advantage of the enolizable ketone functionality present in the cross-coupled product. The methodol. provides an efficient means to form C-C bonds from aliphatic amide derivatives using nonprecious-metal catalysis and offers a general platform for the heteroarylation of aliphatic acyl electrophiles. In addition to this study using 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, there are many other studies that have used 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0Recommanded Product: 847818-74-0) was used in this study.

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Recommanded Product: 847818-74-0

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics