In 2021,Chemical Communications (Cambridge, United Kingdom) included an article by Hara, Naofumi; Uemura, Nao; Nakao, Yoshiaki. Quality Control of 1-Methylpyrazole. The article was titled 《C2-Selective silylation of pyridines by a rhodium-aluminum complex》. The information in the text is summarized as follows:
We have developed a C2-selective dehydrogenative mono-silylation of a variety of pyridines using a Rh-Al complex [(R2PCH2N-1,2-C6H4NMe-1,2-C6H4NCH2PR2)AlClRhCl(L)]n (R = Ph, iPr; n = 1, L = nbd; n = 2, L void). Both the site- and mono-selectivity are controlled via the pyridine coordination to the Lewis-acidic Al center prior to the activation of the pyridine C(2)-H bond at the proximal Rh center. A reaction mechanism is proposed based on several mechanistic studies, including the isolation of a (2-pyridyl)silylrhodium intermediate. In the experimental materials used by the author, we found 1-Methylpyrazole(cas: 930-36-9Quality Control of 1-Methylpyrazole)
1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Quality Control of 1-Methylpyrazole
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics