In 1990,Randow, Hendrik; Miethchen, Ralf published 《Regioselectivity in N-alkylations of pyrazoles and 1,2,4-triazoles》.Wissenschaftliche Zeitschrift der Universitaet Rostock, Naturwissenschaftliche Reihe published the findings.Product Details of 15366-34-4 The information in the text is summarized as follows:
The regioselectivity of the N-alkylation of pyrazoles I (R1 = H, Me, Br, Cl, iodo; R2 = H, Br, iodo; R3 = Me, CO2Me, Br, iodo) and the triazoles II (R4 = Br, Cl) with BrCH2COOMe and, in some cases, MeI is discussed with the help of product NMR data. The experimental process involved the reaction of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Product Details of 15366-34-4)
Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Product Details of 15366-34-4
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics