Pyrazoles are synthesized by the reaction of α,β-unsaturated aldehydes with hydrazine and subsequent dehydrogenation. 2075-46-9, formula is C3H3N3O2, Name is 4-Nitro-1H-pyrazole. Substituted pyrazoles are prepared by condensation of 1,3-diketones with hydrazine (Knorr-type reactions). For example, acetylacetone and hydrazine gives 3,5-dimethylpyrazole. Computed Properties of 2075-46-9.
Li, Bu-Tong;Li, Lu-Lin;Liu, Lin-Li research published 《 Thermal stability and detonation characters of nitro-substituted derivatives of pyrazole》, the research content is summarized as follows. A review. High-energy-d. compounds are designed successively by substituting the hydrogen atoms of 1H-pyrazole by the nitro group. The thermal stabilities are explored by the calculations of the heat of formation, bond orders, and bond dissociation energy at the B3PW91/6-311 + G(d,p) level. To evaluate the potential application as high-energy-d. compounds, the mol. d. (ρ), explosive heat (Q), the detonation velocity and detonation pressure are evaluated by using the empirical Kamlet-Jacobs equation. Based on our calculations, five mols. (3,4,5-trinitro-1H-pyrazole, 1,4,5-trinitro-1H-pyrazole, 1,3,5-trinitro-1H-pyrazole, 1,3,4-trinitro-1H-pyrazole, 1,3,4,5-tetranitro-1H-pyrazole) reached the balance between the stability and detonation characters and can be regarded as the potential high-energy-d. compounds
Computed Properties of 2075-46-9, 4-Nitro-1H-pyrazole, also known as 4-Nitropyrazole, is a useful research compound. Its molecular formula is C3H3N3O2 and its molecular weight is 113.08 g/mol. The purity is usually 95%.
4-Nitropyrazole, is a building block for the synthesis of various pharmaceutical compounds, including inhibitors, and therapeutic agents. It can be used for the synthesis of highly selective, brain-penetrant aminopyrazole LRRK2 Inhibitor, as a potentially viable treatment for Parkinson’s disease., 2075-46-9.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics