Pyrazoles are synthesized by the reaction of α,β-unsaturated aldehydes with hydrazine and subsequent dehydrogenation. 2075-46-9, formula is C3H3N3O2, Name is 4-Nitro-1H-pyrazole. Substituted pyrazoles are prepared by condensation of 1,3-diketones with hydrazine (Knorr-type reactions). For example, acetylacetone and hydrazine gives 3,5-dimethylpyrazole. Computed Properties of 2075-46-9.
Fernandez, Belen;Fernandez, Ignacio;Cepeda, Javier;Medina-ODonnell, Marta;Rufino-Palomares, Eva E.;Raya-Baron, Alvaro;Gomez-Ruiz, Santiago;Perez-Jimenez, Amalia;Lupianez, Jose Antonio;Reyes-Zurita, Fernando J.;Rodriguez-Dieguez, Antonio research published 《 Modulating Anticancer Potential by Modifying the Structural Properties of a Family of Zinc Metal-Organic Chains Based on 4-Nitro-1H-pyrazole》, the research content is summarized as follows. The authors synthesized a novel family of metal-organic chains based on 4-nitro-1H-pyrazole linker and zinc as metal center. The authors report the formation of these coordination polymers using hydrothermal routes with water as solvent. These materials display one-dimensional structures with major structural modifications from minimal synthetic variations. What is more interesting, the authors have carried out antitumor measurements, and the authors have related these properties with the structural networks. To the best of the authors’ knowledge, these materials constitute the first examples of polymeric structures for 4-NO2-pz ligands. NMR and MS spectrometry were used to verify the characterization of the metal complexes in solution to corroborate that these materials are present in the biol. assays.
Computed Properties of 2075-46-9, 4-Nitro-1H-pyrazole, also known as 4-Nitropyrazole, is a useful research compound. Its molecular formula is C3H3N3O2 and its molecular weight is 113.08 g/mol. The purity is usually 95%.
4-Nitropyrazole, is a building block for the synthesis of various pharmaceutical compounds, including inhibitors, and therapeutic agents. It can be used for the synthesis of highly selective, brain-penetrant aminopyrazole LRRK2 Inhibitor, as a potentially viable treatment for Parkinson’s disease., 2075-46-9.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics