The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.Formula: C9H9NO.Koenig, Thomas M.; Mitchell, David published the article 《A convenient method for preparing enantiomerically pure norfluoxetine, fluoxetine and tomoxetine》 about this compound( cas:17190-29-3 ) in Tetrahedron Letters. Keywords: norfluoxetine enantiomeric preparation; fluoxetine enantiomeric preparation; tomoxetine enantiomeric preparation. Let’s learn more about this compound (cas:17190-29-3).
A convenient synthesis for enantiomers of norfluoxetine (I; R = 4-F3C, R1 = H), fluoxetine (I; R = F3C, R1 = Me) and tomoxetine (I: R = R1 = Me) is described. All final products were derived from 3-phenyl-3-hydroxypropylamine, prepared in 2 steps from PhCHO and acetonitrile.
This compound(3-Hydroxy-3-phenylpropanenitrile)Formula: C9H9NO was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics