The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine( cas:52287-51-1 ) is researched.Quality Control of 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine.Jia, Kunfang; Zhang, Fuyuan; Huang, Hanchu; Chen, Yiyun published the article 《Visible-Light-Induced Alkoxyl Radical Generation Enables Selective C(sp3)-C(sp3) Bond Cleavage and Functionalizations》 about this compound( cas:52287-51-1 ) in Journal of the American Chemical Society. Keywords: visible light alkoxy radical bond cleavage functionalization; alc oxidation cyclic iodine reagent; beta fragmentation bond cleavage alkynylation alkenylation cycloalkanol. Let’s learn more about this compound (cas:52287-51-1).
The alkoxyl radical is an important reactive intermediate in mechanistic studies and organic synthesis; however, its current generation from alc. oxidation heavily relies on transition metal activation under strong oxidative conditions. Here we report the first visible light-induced alc. oxidation to generate alkoxyl radicals by cyclic iodine(III) reagent catalysis under mild reaction conditions. The β-fragmentation of alkoxyl radicals enables selective C(sp3)-C(sp3) bond cleavage and alkynylation/alkenylation reactions with various strained cycloalkanols, and for the first time with linear alcs.
Different reactions of this compound(6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine)Quality Control of 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine require different conditions, so the reaction conditions are very important.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics