Kolman, Viktor; Kalcic, Filip; Jansa, Petr; Zidek, Zdenek; Janeba, Zlatko published the article 《Influence of the C-5 substitution in polysubstituted pyrimidines on inhibition of prostaglandin E2 production》. Keywords: pyrimidine preparation SAR prostaglandin E2 inhibitor; Inhibitor; Prostaglandin E(2); Pyrimidines; Suzuki-Miyaura reaction.They researched the compound: 2-Amino-4,6-dichloro-5-methylpyrimidine( cas:7153-13-1 ).Recommanded Product: 7153-13-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:7153-13-1) here.
As a part of a broader structure-activity relationship study of substituted 2-aminopyrimidines, the influence of the C-5 substitution on inhibition of prostaglandin E2 (PGE2) production was studied. Thirty compounds were prepared starting from the corresponding 2-amino-4,6-dichloropyrimidines using Suzuki cross-coupling. It was shown previously that 2-amino-4,6-dichloropyrimidines with smaller C-5 substituent (hydrogen and methyl) were devoid of significant activity, while 5-Bu derivatives exhibited prominent potency. In this study, on the other hand, both monoaryl- and bisarylpyrimidines were potent inhibitors of PGE2 production regardless the length of the C-5 substituent (hydrogen, Me, n-butyl). Moreover, the shorter the C-5 substituent the higher potency to inhibit PGE2 production was observed 2-Amino-4,6-diphenylpyrimidine was the best inhibitor of PGE2 production with IC50 = 3 nM and no cytotoxicity. The most potent inhibitors deserve further preclin. evaluation as potential anti-inflammatory agents.
The article 《Influence of the C-5 substitution in polysubstituted pyrimidines on inhibition of prostaglandin E2 production》 also mentions many details about this compound(7153-13-1)Recommanded Product: 7153-13-1, you can pay attention to it or contacet with the author([email protected]; [email protected]) to get more information.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics