Staples, Jack W.; Stine, Jessica M.; Maki-Lohiluoma, Eero; Steed, Emily; George, Kathleen M.; Thompson, Charles M.; Woodahl, Erica L. published the article 《Food dyes as P-glycoprotein modulators》. Keywords: allurared carmoisine ponceau4R sunset quinolone yellow tartrazine AtPase Pglycoprotein; Drug transporter; Food dye; P-glycoprotein.They researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).SDS of cas: 25956-17-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:25956-17-6) here.
The drug transporter P-glycoprotein (P-gp) is often investigated in drug-interaction studies because the activity is modulated by a wide variety of xenobiotics including drugs, herbal products, and food components. In this study, we tested six common arylsulfonate food dyes-allura red, carmoisine, ponceau 4R, quinolone yellow, sunset yellow, and tartrazine-as activators and inhibitors of P-gp activity in vitro. The dyes were studied as P-gp activators by measuring ATPase activity in P-gp-expressing membranes. Compared to verapamil, a known activator of P-gp, the six food dyes showed no stimulatory activity. The potential for these six food dyes to act as P-gp inhibitors was tested in an intracellular efflux assay with P-gp-expressing cells. Compared to GF120918, a known P-gp inhibitor, there was no inhibitory activity for these six food dyes. The six food dyes tested do not interact with P-gp in vitro and, therefore, are unlikely cause clin. drug-food dye interactions. Further investigation is necessary to determine whether these food dyes could interact with other drug transporters.
After consulting a lot of data, we found that this compound(25956-17-6)SDS of cas: 25956-17-6 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics