Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 17190-29-3, is researched, Molecular C9H9NO, about Turning the ‘mustard oil bomb’ into a ‘cyanide bomb’: aromatic glucosinolate metabolism in a specialist insect herbivore, the main research direction is Pieris benzylglucosinolate metabolism cyanide Arabidopsis dhurrin.Related Products of 17190-29-3.
Plants have evolved a variety of mechanisms for dealing with insect herbivory among which chem. defense through secondary metabolites plays a prominent role. Physiol., behavioral and sensorical adaptations to these chems. provide herbivores with selective advantages allowing them to diversify within the newly occupied ecol. niche. In turn, this may influence the evolution of plant metabolism giving rise to e.g., new chem. defenses. The association of Pierid butterflies and plants of the Brassicales has been cited as an illustrative example of this adaptive process known as ‘coevolutionary armsrace’. All plants of the Brassicales are defended by the glucosinolate-myrosinase system to which larvae of cabbage white butterflies and related species are biochem. adapted through a gut nitrile-specifier protein. Here, the authors provide evidence by metabolite profiling and enzyme assays that metabolism of benzylglucosinolate in Pieris rapae results in release of equimolar amounts of cyanide, a potent inhibitor of cellular respiration. The authors further demonstrate that P. rapae larvae develop on transgenic Arabidopsis plants with ectopic production of the cyanogenic glucoside dhurrin without ill effects. Metabolite analyses and fumigation experiments indicate that cyanide is detoxified by β-cyanoalanine synthase and rhodanese in the larvae. Based on these results as well as on the facts that benzylglucosinolate was one of the predominant glucosinolates in ancient Brassicales and that ancient Brassicales lack nitrilases involved in alternative pathways, the authors propose that the ability of Pierid species to safely handle cyanide contributed to the primary host shift from Fabales to Brassicales that occurred about 75 million years ago and was followed by Pierid species diversification.
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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics