Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Easy direct stereo- and regioselective formation of β-hydroxy nitriles by reaction of 1,2-epoxides with potassium cyanide in the presence of metal salts.Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile.
The metal salt-catalyzed ring opening of epoxides with KCN in MeCN gave regioselectively and stereoselectively β-hydroxy nitriles. The ring opening reaction is regioselective with attack of the nucleophile only on the sterically less hindered carbon. Treatment of (±)-1-hexyloxirane with KCN/LiCLO4 in MeCN gave 95% C5H11CH(OH)CH2CH2CN (97.0% attack at the β-carbon and 1.8% attack at the α-carbon). The ring opening reaction is anti-stereoselective, whereby only the trans isomer of the β-hydroxy nitriles were formed. Ring opening of (+)-1,2-epoxycyclohexane gave 96% trans-3-hydroxy-1-cyclohexanecarbonitrile. With styrene oxide attack of the nucleophile occurred also on the more substituted benzylic carbon.
From this literature《Easy direct stereo- and regioselective formation of β-hydroxy nitriles by reaction of 1,2-epoxides with potassium cyanide in the presence of metal salts》,we know some information about this compound(17190-29-3)Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile, but this is not all information, there are many literatures related to this compound(17190-29-3).
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics