Application of 17190-29-3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Novel multiaction of Zr catalyst: one-pot synthesis of β-cyanohydrins from olefins. Author is Yamasaki, Shingo; Kanai, Motomu; Shibasaki, Masakatsu.
A general one-pot synthesis of β-cyanohydrins, e.g., I (n = 1-4), from olefins, e.g., II, promoted by Zr diolate catalysts, is presented. E.g., Zr(OCMe3)4 was added to a mixture of triphenylphosphine oxide and Ph2C(OH)CH2CH2C(OH)Ph2 in 1,2-dichloroethane at 0° and stirred for 10 min. to yield a solution with 5 mol% catalyst; 2 equivalent of bis(trimethylsilyl)peroxide, 2 equivalent trimethylsilyl cyanide, and cyclohexene were added and the mixture stirred for 12 h to give I (n = 2) in 95% yield. The mechanism involves epoxidation and ring opening with the zirconium acting as a catalyst for both processes; a mechanism for the action of the zirconium diolate catalyst is proposed. The kinetics of both processes are examined Using a nonracemic TADDOL analog, cyanohydrin III was prepared enantioselectively in 85% yield and 62% ee under similar conditions.
There is still a lot of research devoted to this compound(SMILES：N#CCC(O)C1=CC=CC=C1)Application of 17190-29-3, and with the development of science, more effects of this compound(17190-29-3) can be discovered.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics