The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Amino-4,6-dichloro-5-methylpyrimidine(SMILESS: CC1=C(N=C(N)N=C1Cl)Cl,cas:7153-13-1) is researched.Electric Literature of C17H18Cl2N2. The article 《Combining Quantum Mechanical Ligand Conformation Analysis and Protein Modeling to Elucidate GPCR-Ligand Binding Modes》 in relation to this compound, is published in ChemMedChem. Let’s take a look at the latest research on this compound (cas:7153-13-1).
2-Aminopyrimidine ligands with flexible and rigid side chains was synthesized to investigate the role of ligand conformation in H4R ligand binding. The ligand binding conformations and orientations in the H4R binding pocket was elucidated. The combined ligand- and protein-ligand modeling method can be used as a general approach to investigate the binding modes of flexible side chains of ligands with other protein targets.
If you want to learn more about this compound(2-Amino-4,6-dichloro-5-methylpyrimidine)Related Products of 7153-13-1, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(7153-13-1).
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics