Grassl, Simon; Singer, Johannes; Knochel, Paul published the article 《Iron-Mediated Electrophilic Amination of Organozinc Halides using Organic Azides》. Keywords: secondary amine preparation; organozinc chloride azide electrophilic amination iron mediated; azides; electrophilic amination; iron-mediated amination; organozinc halides; secondary amines.They researched the compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine( cas:52287-51-1 ).Synthetic Route of C8H7BrO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:52287-51-1) here.
A wide range of alkyl-, aryl- and heteroarylzinc halides were aminated with highly functionalized alkyl, aryl, and heterocyclic azides. The reaction proceeded smoothly at 50 °C within 1 h in the presence of FeCl3 (0.5 equiv) to furnish the corresponding secondary amines such as RNHR1 [R = 4-MeOC6H4, 3,5-di-MeC6H3, 6-chloro-3-pyridyl, etc.; R1 = cyclopropyl, 4-FC6H4, 4-ClC6H4, etc.] in good yields. This method was extended to peptidic azides and provided the arylated substrates with full retention of configuration. To demonstrate the utility of this reaction, prepared two amine derivatives of pharmaceutical relevance using this iron-mediated electrophilic amination as the key step.
If you want to learn more about this compound(6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine)Synthetic Route of C8H7BrO2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(52287-51-1).
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics