Recently I am researching about POSTTRAUMATIC-STRESS-DISORDER; POPULATION-BASED SAMPLE; EMOTIONAL ABUSE; ELEVATED RISK; LIFE; ADVERSITY; HEALTH; MALTREATMENT; VICTIMIZATION; RECOLLECTIONS, Saw an article supported by the US National Institutes of Health (NIH)United States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [K23 AR071500]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [R01 AR057327, K24 AR066109]; [UM1 CA176726]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Cancer Institute (NCI) [UM1CA176726] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) [K23AR071500, R01AR057327, K24AR066109] Funding Source: NIH RePORTER. Published in J RHEUMATOL PUBL CO in TORONTO ,Authors: Feldman, CH; Malspeis, S; Leatherwood, C; Kubzansky, L; Costenbader, KH; Roberts, AL. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole. Recommanded Product: 67-51-6
Objective. Exposure to severe stressors may alter immune function and augment inflammation and cytokine release, increasing risk of autoimmune disease. We examined whether childhood abuse was associated with a heightened risk of incident systemic lupus erythematosus (SLE). Methods. Data were drawn from the Nurses’ Health Study II, a cohort of US female nurses enrolled in 1989, followed with biennial questionnaires. We measured childhood physical and emotional abuse with the Physical and Emotional Abuse Subscale of the Childhood Trauma Questionnaire and sexual abuse with the Sexual Maltreatment Scale of the Parent-Child Conflict Tactics Scale, both administered in 2001. We identified incident SLE (>= 4 American College of Rheumatology 1997 classification criteria) through 2015. We used multivariable Cox regression models to evaluate the association between childhood abuse and SLE, accounting for potential confounders (e.g., parental education, occupation, home ownership) and mediators [e.g., depression, posttraumatic stress disorder (PTSD)]. Results. Among 67,516 women, there were 94 cases of incident SLE. In adjusted models, exposure to the highest versus lowest physical and emotional abuse was associated with 2.57 times greater risk of SLE (95% CI 1.30-5.12). We found that 17% (p < 0.0001) of SLE risk associated with abuse could be explained by depression and 23% (p < 0.0001) by PTSD. We did not observe a statistically significant association with sexual abuse (HR 0.84, 95% CI 0.40-1.77, highest vs lowest exposure). Conclusion. We observed significantly increased risk of SLE among women who had experienced childhood physical and emotional abuse compared with women who had not. Exposure to childhood adversity may contribute to development of SLE. Recommanded Product: 67-51-6. Welcome to talk about 67-51-6, If you have any questions, you can contact Feldman, CH; Malspeis, S; Leatherwood, C; Kubzansky, L; Costenbader, KH; Roberts, AL or send Email.
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