Recommanded Product: 67-51-6. Recently I am researching about ASICS; PHARMACOLOGY; DIMINAZENE; ASSAY; PH, Saw an article supported by the COLLEZIONE DEI COMPOSTI CHIMICI E CENTRO DI SCREENING-CNCCS scarl. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Bencheva, LI; De Matteo, M; Ferrante, L; Ferrara, M; Prandi, A; Randazzo, P; Ronzoni, S; Sinisi, R; Seneci, P; Summa, V; Gallo, M; Veneziano, M; Cellucci, A; Mazzocchi, N; Menegon, A; Di Fabio, R. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole
Acid-sensing ion channels (ASICs) are a family of ion channels permeable to cations and largely responsible for the onset of acid-evoked ion currents both in neurons and in different types of cancer cells, thus representing a potential target for drug discovery. Owing to the limited attention ASIC2 has received so far, an exploratory program was initiated to identify ASIC2 inhibitors using diminazene, a known pan-ASIC inhibitor, as a chemical starting point for structural elaboration. The performed exploration enabled the identification of a novel series of ASIC2 inhibitors. In particular, compound 2u is a brain penetrant ASIC2 inhibitor endowed with an optimal pharmacokinetic profile. This compound may represent a useful tool to validate in animal models in vivo the role of ASIC2 in different neurodegenerative central nervous system pathologies.
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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics