A common compound: 26621-44-3, name is 3-Nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 26621-44-3
Sodium hydride (0.425 g of a 60%dispersion in mineral oil, 10.612 mmol) was added to a solution of 3-nitro-1H-pyrazole (1.000 g, 8.843 mmol) in 40 mL of THF at 0 C and the mixture was stirred for 10 min. SEM-Cl (1.72 mL, 9.727 mmol) was added dropwise and the mixture was stirred at r.t. for 1 h. The reaction mixture was diluted ethyl acetate and washed with brine. The organic phase was dried over Na2SO4, concentrated and purified by silica gel flash chromatography (EA: PE =0 to 40%) to give 1.8 g of the title compound. Yield: 86%. MS (ESI, m/e) : 244 [M+1] +.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 26621-44-3, other downstream synthetic routes, hurry up and to see.