35277-02-2, Name is 4-Fluoro-1H-pyrazole, 35277-02-2, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
To a solution of [3-[2-(9-cyano-3,5- dihydro-2H-pyrido[3,4-f][l,4]oxazepin-4-yl)-l,l-dimethyl-2-oxo-ethyl]cyclobutyl] methanesulfonate (200 mg, 0.51 mmol) and 4-fluoro-lH-pyrazole (88 mg, 1.02 mmol) in DMF (2 mL) was added CS2CO3 (331 mg, 1.02 mmol) at 25 C, and then the solution was stirred at 100 C for 12 h. The reaction mixture was partitioned between DCM/i-PrOH (v:v = 3 : 1, 3 x 10 mL) and water (5 mL). The organic phase was separated, washed with brine (5 mL), dried over anhydrous Na2S04, filtered and concentrated under reduced pressure. The residue was purified by prep-HPLC with the following conditions: column: Xtimate C18 150 25 mm 5 muiotaeta; mobile phase: [water (10 mM H4HC03)-ACN]; B%: 30%-50% over 10.5 min. to provide the title compound as a light yellow oil. LCMS: m/z = 384.4 [M+H]+.
Statistics shows that 4-Fluoro-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 35277-02-2.