As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2075-46-9 name is 4-Nitro-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 2075-46-9
Step 1 To a solution of 4-nitro-lH-pyrazole (100 g, 0.88 mol) in ACN (2L) was added K2C03 (183.2 g, 1.33 mol) and methyl 2-chloroacetate (95.6 g, 0.88 mol). The mixture was warmed to 60C and stirred for 5h. The mixture was then filtered and solvent removed to give methyl 2-(4- nitro-lH-pyrazol-l-yl)acetate as a white solid (150 g, 92%). 1H NMR (400 MHz CDC13): delta 8.28 (s, 1H), 8.11 (s, 1H), 4.98 (s, 2H), 3.84 (s, 3H),
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Nitro-1H-pyrazole, and friends who are interested can also refer to it.