Safety of 3,5-Dimethyl-1H-pyrazole. I found the field of Chemistry very interesting. Saw the article Universal Anticancer Cu(DTC)(2) Discriminates between Thiols and Zinc(II) Thiolates Oxidatively published in 2019.0, Reprint Addresses Lin, BL (corresponding author), ShanghaiTech Univ, Sch Phys Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China.; Wang, Y (corresponding author), Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Shanghai Adv Res Inst, 239 Zhangheng Rd, Shanghai 201204, Peoples R China.; Deng, W (corresponding author), Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Haiquan Rd, Shanghai 201418, Peoples R China.; Lin, BL (corresponding author), Chinese Acad Sci, Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China.; Lin, BL (corresponding author), Univ Chinese Acad Sci, Beijing 100049, Peoples R China.. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole.
Aerobic organisms must rely on abundant intracellular thiols to reductively protect various vital functional units, especially ubiquitous zinc(II) thiolate sites of proteins, from deleterious oxidations resulting from oxidizing environments. Disclosed here is the first well-defined model study for reactions between zinc(II) thiolate complexes and copper(II) complexes. Among all the studied ligands of copper(II), diethyldithiocarbamate (DTC) displays a unique redox-tuning ability that enables copper(II) to resist the reduction by thiols while retaining its ability to oxidize zinc(II) thiolates to form disulfides. This work proves for the first time that it is possible to develop oxidants to discriminate between thiols and zinc(II) thiolates, alluding to a new chemical principle for how oxidants, especially universal anticancer Cu(DTC)(2), might circumvent the intracellular reductive defense around certain zinc(II) thiolate sites of proteins to kill malignant cells.
Safety of 3,5-Dimethyl-1H-pyrazole. Welcome to talk about 67-51-6, If you have any questions, you can contact Xu, LY; Xu, JL; Zhu, JW; Yao, ZJ; Yu, N; Deng, W; Wang, Y; Lin, BL or send Email.
Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics