Recently I am researching about ARYL FLUORIDES; BOND FORMATION; AMINATION; ACTIVATION, Saw an article supported by the National Institutes of Health (NIGMS)United States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [R01 GM120186]; NSF Graduate Research Fellowship ProgramNational Science Foundation (NSF); U.S. Department of Energy, Office of Science, Office of Basic Energy SciencesUnited States Department of Energy (DOE) [DE-SC0001011]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Pistritto, VA; Schutzbach-Horton, ME; Nicewicz, DA. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole. Application In Synthesis of 3,5-Dimethyl-1H-pyrazole
Nucleophilic aromatic substitution (SNAr) is a classical reaction with well-known reactivity toward electron-poor fluoroarenes. However, electron-neutral and electron-rich fluoro(hetero)arenes are considerably underrepresented. Herein, we present a method for the nucleophilic defluorination of unactivated fluoroarenes enabled by cation radical-accelerated nucleophilic aromatic substitution. The use of organic photoredox catalysis renders this method operationally simple under mild conditions and is amenable to various nucleophile classes, including azoles, amines, and carboxylic acids. Select fluorinated heterocycles can be functionalized using this method. In addition, the late-stage functionalization of pharmaceuticals is also presented. Computational studies demonstrate that the site selectivity of the reaction is dictated by arene electronics.
Application In Synthesis of 3,5-Dimethyl-1H-pyrazole. Welcome to talk about 67-51-6, If you have any questions, you can contact Pistritto, VA; Schutzbach-Horton, ME; Nicewicz, DA or send Email.
Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics