I found the field of Chemistry very interesting. Saw the article Switching the site-selectivity of C-H activation in aryl sulfonamides containing strongly coordinating N-heterocycles published in 2019.0. Safety of 3,5-Dimethyl-1H-pyrazole, Reprint Addresses Xu, H (corresponding author), Chinese Acad Med Sci, Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.; Xu, H (corresponding author), Chinese Acad Med Sci, Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Act Subst Discovery & Druggabil E, Beijing 100050, Peoples R China.. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole
The limitations of arene C-H functionalization of aryl sulfonamides containing strongly coordinating Nheterocycles were overcome using a Rh(III) catalyst. The site-selectivity of C-H carbenoid functionalization at the ortho position relative to either the sulfonamide or N-heterocycle directing groups was elegantly switched using solvents of different polarities and different additive concentrations. Importantly, sulfonamide-group-directed ortho-C-H carbenoid functionalization tolerated strongly coordinating N-heterocycles, including pyridine, pyrrole, thiazole, pyrimidine, and pyrazine. Density functional theory (DFT) calculations were performed to rationalize the reaction mechanisms and the influence of reaction polarity.
About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Dong, Y; Zhang, XP; Chen, JJ; Zou, WX; Lin, SW; Xu, H or concate me.. Category: pyrazoles-derivatives
Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics