An overview of features, applications of compound:67-51-6

Safety of 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Bellenie, BR; Cheung, KMJ; Varela, A; Pierrat, OA; Collie, GW; Box, GM; Bright, MD; Gowan, S; Hayes, A; Rodrigues, MJ; Shetty, KN; Carter, M; Davis, OA; Henley, AT; Innocenti, P; Johnson, LD; Liu, MJ; de Klerk, S; Le Bihan, YV; Lloyd, MG; McAndrew, PC; Shehu, E; Talbot, R; Woodward, HL; Burke, R; Kirkin, V; van Montfort, RLM; Raynaud, FI; Rossanese, OW; Hoelder, S or concate me.

Recently I am researching about GERMINAL CENTER; INTERACTION INHIBITOR; PROTEIN-DEGRADATION; HALLMARKS; PEPTIDE; VITRO, Saw an article supported by the Cancer Research UKCancer Research UK [C309/A11566]; CRT Pioneer Fund; Sixth Element Capital; NHS. Safety of 3,5-Dimethyl-1H-pyrazole. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Bellenie, BR; Cheung, KMJ; Varela, A; Pierrat, OA; Collie, GW; Box, GM; Bright, MD; Gowan, S; Hayes, A; Rodrigues, MJ; Shetty, KN; Carter, M; Davis, OA; Henley, AT; Innocenti, P; Johnson, LD; Liu, MJ; de Klerk, S; Le Bihan, YV; Lloyd, MG; McAndrew, PC; Shehu, E; Talbot, R; Woodward, HL; Burke, R; Kirkin, V; van Montfort, RLM; Raynaud, FI; Rossanese, OW; Hoelder, S. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole

Deregulation of the transcriptional repressor BCL6 enables tumorigenesis of germinal center B-cells, and hence BCL6 has been proposed as a therapeutic target for the treatment of diffuse large B-cell lymphoma (DLBCL). Herein we report the discovery of a series of benzimidazolone inhibitors of the protein-protein interaction between BCL6 and its co-repressors. A subset of these inhibitors were found to cause rapid degradation of BCL6, and optimization of pharmacokinetic properties led to the discovery of 5-((5-chloro-2-((3R,SS)-4,4-difluoro-3,5-dimethylpiperi din-1-yl) pyrimidin-4-yl) amino)-3-(3-hydroxy-3-methylbutyl)-1-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one (CCT369260), which reduces BCL6 levels in a lymphoma xenograft mouse model following oral dosing.

Safety of 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Bellenie, BR; Cheung, KMJ; Varela, A; Pierrat, OA; Collie, GW; Box, GM; Bright, MD; Gowan, S; Hayes, A; Rodrigues, MJ; Shetty, KN; Carter, M; Davis, OA; Henley, AT; Innocenti, P; Johnson, LD; Liu, MJ; de Klerk, S; Le Bihan, YV; Lloyd, MG; McAndrew, PC; Shehu, E; Talbot, R; Woodward, HL; Burke, R; Kirkin, V; van Montfort, RLM; Raynaud, FI; Rossanese, OW; Hoelder, S or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics