Recently I am researching about 2+2 PHOTOCYCLOADDITION REACTIONS; ENANTIOSELECTIVE SYNTHESIS; CASCADE REACTION; CYCLOADDITION; CATALYSIS; ENALS, Saw an article supported by the Guangzhou University of Chinese Medicine, Pearl River Talents Recruitment Program of Guangdong Province [2017GC010361]; Department of Education of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016KCXTD015]; Jiangmen Program for I nnovative Research Team [2018630100180019806]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Chen, YZ; Wang, YC; Wang, SZ; Ma, YY; Zhao, DG; Zhan, RT; Huang, HC. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole. Name: 3,5-Dimethyl-1H-pyrazole
The construction of cyclobutanes has attracted much attention because of its unique four-membered ring skeleton. Herein, we report the highly enantioselective direct vinylogous Michael reaction of beta,gamma-unsaturated pyrazole amides and nitroolefin using a squaramide catalyst. Cyclobutane derivatives were obtained by subsequent cyclization in good yields (up to 85%) with excellent enantioselectivities (up to 99% ee). Importantly, the large-scale reaction experiment confirmed the reliability of the vinylogous reaction. Furthermore, the synthetic utility of the vinylogous adducts and cyclobutane derivatives has been realized.
Name: 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Chen, YZ; Wang, YC; Wang, SZ; Ma, YY; Zhao, DG; Zhan, RT; Huang, HC or concate me.
Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics