Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1453-58-3, name is 3-Methylpyrazole, A new synthetic method of this compound is introduced below., Formula: C4H6N2
3-Methyl-1H-pyrazole (0.66 g, 8 mmol) and potassium tertbutoxide (0.88 g, 7.8 mmol) were dissolved in dry dimethyl sulfoxide (DMSO) (5 mL) at room temperature. To the basic solution, 2-bromopyridine (1.17 g, 7.4 mmol) was added slowly under constant stirring, and the solution was heated to reflux under nitrogen for 12 h. Once the reaction completed, it was cooled to room temperature and extracted with water and ether. The organic layer was washed withwater and ether to remove DMSO and excess base. The organic layer was then isolated, dried over anhydrous Na2SO4, and filtered. The solvent was then removed under reduced pressure, and the resultant colorless oil was purified by column chromatography on silica gel (200e300 mesh) eluted with hexane/ethylacetate (9:1 v/v). 1H NMR (500 MHz, CD2Cl2) delta (ppm): 8.43 (1H, d, J 2.53), 8.38 (1H, d, J 4.88), 7.91 (1H, d, J 8.30), 7.79e7.74 (1H, m), 7.59-7.47 (1H, m), 6.25 (1H, d, J 2.53), 2.38 (3H, s).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Sunesh, Chozhidakath Damodharan; Subeesh, Madayanad Suresh; Shanmugasundaram, Kanagaraj; Chitumalla, Ramesh Kumar; Jang, Joonkyung; Choe, Youngson; Dyes and Pigments; vol. 128; (2016); p. 190 – 200;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics