Adding a certain compound to certain chemical reactions, such as: 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127107-23-7, Product Details of 127107-23-7
. Into a 2000-mL 3-necked round-bottom flask, were placed a solution of intermediate 24.3 (56 g, 152.22 mmol, 1.00 equiv) in n-butanol (1000 mL) and 1- methyl-1H-pyrazol-4-amine hydrochloride (40.89 g, 306.11 mmol, 2.01 equiv). The reaction was stirred overnight at 110 C in an oil bath. Upon completion, the reaction was cooled to room temperature solids were collected by filtration and the resulting solution was diluted with 500 mL of H20. The pH value of the solution was adjusted to 10 with sodium hydroxide (1 mol/L). The resulting solids were collected by filtration and dried in an oven under reduced pressure to furnish 61.9 g (95%) of compound 1-24 as an off-white solid. LCMS: (ES, m/z):429 [M+H] ?HNMR: (400MHz, CD3OD): ?5 7.877(1H, s), 7.568(1H, s), 4.044(1H, s), 3.887(3H, s), 3.751- 3.740(4H, d), 2.692-.2638(7H, m), 2.343(1H, s), 2.264(2H, s), 2.099(2H, s), 1.514-1.392(4H, m).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; NIMBUS IRIS, INC.; ROMERO, Donna L.; MASSE, Craig E.; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine; WO2015/48281; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics