Related Products of 852227-86-2, These common heterocyclic compound, 852227-86-2, name is 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
D-15 D-16Step 4. A mixture of D-15 (210 mg, 0.78 mmol) and cesium carbonate (765 mg, 2.35 mmol) in DMF (25 mL) was heated to 60C with stirring then a solution of 5-(chloromethyl)-1 ,3-dimethyl-1 H-pyrazole (1 13 mg, 0.78 mmol) in DMF(10 mL) was added drop wise. The reaction mixture was stirred for 1 hour at 60C. The solids were removed by filtration and the solvent was removed under reduced pressure. Crude D-16 was used as such in the next step.LC-MS: Anal. Calcd. For CisHasNeOs: 376.22; found 377 [M+H]+
The synthetic route of 852227-86-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN R&D IRELAND; MC GOWAN, David; RABOISSON, Pierre Jean-Marie Bernard; EMBRECHTS, Werner; JONCKERS, Tim, Hugo, Maria; LAST, Stefaan, Julien; PIETERS, Serge, Maria, Aloysius; VLACH, Jaromir; WO2012/136834; (2012); A1;,
Pyrazole – Wikipedia,
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