Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 1280210-79-8
under nitrogen protection, Intermediate 2(604 mg, 2.87mmol) is dissolved in tetrahydrofuran (20 ml) in, lowering the temperature to 0 C, adding sodium hydride to (180 mg, 60 wt %, 4.5mmol), stirring 30 minutes. Then cyclopropyl sulfonyl chloride (1.27g, 9.0mmol), natural temperature to react at room temperature for 1 hour. Adding water to the reaction solution (20 ml) in the quenching of the reaction, ethyl acetate (20mL × 2) extraction, the combined organic layer, drying with anhydrous sodium sulfate, concentrated, re-dissolved in 5 ml of tetrahydrofuran, cooled to -10 C to 0 C, adding 3rd butanol potassium (36 mg, 0.32mmol), this temperature is kept under reaction 28 hours. The end of the reaction, adding citric acid aqueous solution (1 ml, 15%), the addition of water (10 ml), ethyl acetate (20mL × 3) extraction, the combined organic layer, drying with anhydrous sodium sulfate, concentrated. Silica gel column chromatography separation and purification of the residue (petroleum ether/ethyl acetate (v/v)=2:1), to obtain white solid1a (660 mg, yield 73%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SICHUAN HAISCO PHARMACEUTICAL CO., LTD; ZHANG, CHEN; FAN, JIANG; LI, CAI-HU; WEI, YONG-GANG; (99 pag.)TW2017/8222; (2017); A;,
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