Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25016-12-0, name is 1,3-Dimethyl-1H-pyrazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives
To a suspension of tert-butyl 5-((2-amino-5-chloro-3-nitropyridin-4- yl)amino)hexahydrocyclo- penta[c]pyrrole-2(lH)-carboxylate (0.62 g, 1.60 mmol) and 1,3- dimethylpyrazole-4-carbaldehyde (0.22 g, 1.78 mmol) in EtOH (30.0 mL) was added a freshly prepared aqueous solution of sodium dithionite (6.30 mL, 6.30 mmol, 1.0 mol/L). The mixture was heated at 85 C overnight. The mixture was concentrated in vacuo. The residue was purified by silica gel column chromatography (DCM/MeOH (v/v) = 50/1 to 30/1 to 20/1) to afford the title compound as a white solid (0.50g, yield 68%).MS (ESI, pos. ion) m/z: 472.3 [M+H]+; MR (600 MHz, CDC ) delta (ppm): 7.87 (s, 1H), 7.72 (s, 1H), 5.49 – 5.39 (m, 1H), 5.03 (d, J = 8.4 Hz, 1H), 3.92 (s, 3H), 3.58 – 3.48 (m, 2H), 3.46 – 3.33 (m, 2H), 2.80 – 2.72 (m, 2H), 2.69 – 2.60 (m, 5H), 1.50 (s, 9H), 1.48 – 1.40 (m, 2H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Xiaobo; LI, Mingxiong; ZHANG, Tao; HU, Haiyang; WU, Yanjun; (139 pag.)WO2018/169700; (2018); A1;,
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