Reference of 16617-46-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Following the procedure described in Example 11 wherein dioxane was used as the solvent instead of tetrahydrofuran and hexane was added instead of water after the reaction was completed, 86percent of the product was obtained with m. p. 183-187 °C Example 13 Following the procedure described in Example 1 wherein hydrobromic acid was used as the catalyst instead of hydrochloric acid, 81percent of the product was obtained with m. p. 184- 188 °C.
The synthetic route of 3-Amino-1H-pyrazole-4-carbonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ZENTIVA, A.S.; WO2004/37824; (2004); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics