Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 49633-25-2, name is 3-Isopropylpyrazole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 3-Isopropylpyrazole
A mixture of 2-chloro-4-fluoropyridine (23.88 g, 181.56 mmol), 3 -isopropyl -IH- pyrazole (20 g, 181.56 mmol), K2C03 (37.64 g, 272.34 mmol), and NMP (200 mL) was stirred at 100 C overnight under N2. The reaction mixture was allowed to cool to rt, poured into water (800 mL), and then extracted with EtOAc (3 x 200 mL). The combined organic layers were washed with brine (200 mL), dried over Na2S04, filtered, concentrated, and then purified by silica gel chromatography (petroleum ether/ethyl acetate=9/l) to give 2-chloro-4- (3-isopropyl-lif-pyrazol-l-yl)pyridine (9 g) as a colorless oil. 1H NIV1R (400MHz, CDCf): d 8.38 (d, 1H), 7.90 (d, 1H), 7.68 (d, 1H), 7.52 (d, 1H), 6.39 (d, 1H), 3.15-2.97 (m, 1H), 1.32 (d, 6H); LCMS: 222.1 [M+H]+.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 49633-25-2.
Reference:
Patent; METACRINE, INC.; SMITH, Nicholas D.; GOVEK, Steven P.; LAI, Andiliy G.; (0 pag.)WO2020/61118; (2020); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics