852227-86-2, name is 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C6H9ClN2
A mixture of N-(1 -methylcyclopropyl)-3-[(1 -metriylpyrazol-4-yl)metriyl]-2-oxo- 7H-quinoline-6-sulfonamide (60 mg, 0.16 mmol), 5-(chloromethyl)-1 ,3-dimethyl- 1H -pyrazole (23 mg, 0.16 mmol), potassium carbonate (45 mg, 0.32 mmol) and potassium iodide (27 mg, 0.16 mmol) in DMF (2 mL) was heated with agitation in the microwave at deltaOmicron ‘ for 30 minutes. The solvent was removed in vacuo and the residue purified by prep HPLC (high pH) affording the desired product (20 mg, 0.042 mmol, 26%) as a white powder.
The synthetic route of 852227-86-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; MCGONAGLE, Alison E.; JORDAN, Allan; WASZKOWYCZ, Bohdan; HUTTON, Colin; WADDELL, Ian; HITCHIN, James R.; SMITH, Kate Mary; HAMILTON, Niall M.; (497 pag.)WO2016/92326; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics