In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 132712-71-1 as follows. Quality Control of 3-Methyl-1H-pyrazol-5-ol
General procedure: Dichloromethane (10 mL) was taken in a round-bottomed flask,into which 1.0 equivalent (1 mmol) of triethylamine and pyrazolonewere poured. The mixture was stirred for 2 min without heating. To this mixture, 1.0 equivalent of corresponding presynthesized benzylidene from malononitrile was added. Then the mixture was agitated for 25-30 min. The reaction was observed by TLC. The desired products appeared as precipitates. The precipitates were washed with water to remove the unreacted pyrazolone to obtain pure products. Melting points were recordedfor crystalline substances.
According to the analysis of related databases, 132712-71-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Kashtoh, Hamdy; Muhammad, Munira Taj; Khan, Jalaluddin J.A.; Rasheed, Saima; Khan, Ajmal; Perveen, Shahnaz; Javaid, Kulsoom; Atia-Tul-Wahab; Khan, Khalid Mohammed; Choudhary, M. Iqbal; Bioorganic Chemistry; vol. 65; (2016); p. 61 – 72;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics