Reference of 694-48-4, The chemical industry reduces the impact on the environment during synthesis 694-48-4, name is 1,3-Dimethyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.
Put 100g (1.04mol, 1eq) of 1,3-dimethylpyrazole into the reaction bottleWith 400 mL of ethanol, 166.4 g (1.04 mol, 1.00 eq) of bromine was added dropwise with stirring at 5-10C.React at 5-10 for 4 hours,Sampling GC to check the remaining material is less than 1%, add 300mL water,Then add 200mL of saturated aqueous sodium thiosulfate solution to quench,Distilling ethanol under reduced pressure, cooling to 0 ,Filtered180.2g of 4-bromo-1,3-dimethyl-1H-pyrazole,GC purity 94.3%,The yield is 99%
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Dimethyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Xuzhou Shengyuan Chemical Co., Ltd.; Chen Hong; Yu Wanli; (8 pag.)CN111233768; (2020); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics