Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1192-21-8
A magnetically stirred solution of amine 5 (10.0 g, 103 mmol) inTHF (250 mL) was treated with potassium tert-butoxide (23.0 g,205 mmol) at 0 C. The resultant suspension was brought to roomtemperature and stirred for 1 h before the dropwise addition of ofluoronitrobenzene(12 mL, 113 mmol). The reaction mixture wasstirred for 3 h, quenched with water (300 mL) and extracted withEtOAc (3 150 mL). The combined organic extracts were dried(MgSO4), filtered and concentrated under reduced pressure. Thecrude oil was purified by flash column chromatography (silica, 3:5v/v EtOAc:hexanes) and concentration of the relevant fractions(Rf 0.42 in 1:1 v/v EtOAc:hexanes) afforded the title compound(16.9 g, 77percent) as yellow crystals.1H NMR (300 MHz, Chloroform-d): d 9.11 (s, 1H, NH), 8.25 (d,J 8.1 Hz, 1H), 7.56e7.54 (m, 1H), 7.52e7.38 (m, 1H), 6.96e6.84 (m,1H), 6.78e6.74 (m, 1H), 6.20 (d, J 2.5 Hz, 1H), 3.76 (s, 3H). 13C NMR(75 MHz, Chloroform-d): d 142.7, 139.0, 136.8, 136.3, 133.4, 126.6,118.7, 115.8, 101.8, 35.2. IR (diamond cell, neat) nmax: 3297, 3094,1609, 1572, 1509, 1490, 1340, 1221, 1145, 1075, 1043, 927, 750 cm1.LRMS (ESI) m/z: 219 ([MH], 100percent). HRMS (ESI) Found:(MNa), 241.0697. C10H10N4O2 requires (MNa), 241.0696. MP:133e135 C.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1192-21-8.
Reference:
Article; Jorgensen, William T.; Gulliver, Damien W.; Katte, Timothy A.; Werry, Eryn L.; Reekie, Tristan A.; Connor, Mark; Kassiou, Michael; European Journal of Medicinal Chemistry; vol. 143; (2018); p. 1644 – 1656;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics