Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3528-45-8, name is 1-(4-Methoxybenzyl)-1H-pyrazol-5-amine, A new synthetic method of this compound is introduced below., Product Details of 3528-45-8
To an ice-cooled solution of 2-(4-methoxy-benzyl)-2eta-pyrazol-3-ylamine (406 mg, 2.0 mmol, 1.0 eq.) in DCM (5 mL), DIPEA (0.52 ml, 3.0 mmol, 1.5 eq.) was added.A solution of bromoacetyl bromide (0.19 ml, 2.2 mmol, 1.1 eq.) in DCM (2 mL) was added dropwise. The cooling bath was removed and the brown solution was stirred at r.t. for 1.5 hours. The solution was diluted with AcOEt (75 mL), washed with sat. aq.NaHCO3 soln. (1 x 40 mL), with sat. aq. NaCl soln. (1 x 40 mL), dried over MgSO4, and concentrated in vacuo. The residue was purified by CC (SiO2, AcOEt/Hept 1 :1 to6:4) to give the desired bromide as a beige solid.LC-MS (A): tR = 2.60 min; [M-H]+ = 322.3.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/150614; (2009); A1;,
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