Discovery of 1018446-95-1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, its application will become more common.

Synthetic Route of 1018446-95-1,Some common heterocyclic compound, 1018446-95-1, name is tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, molecular formula is C8H13N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(C) 1-(2-(2-(2-((1H-Pyrazol-4-yI) amino) -5-methylpyrimidin-4-yI) ethyl)phenyl) cyclopropanecarboxamide (46)A mixture of 1-(2-(2-(2-chloro-5-methylpyrimidin-4-yl)ethyl) phenyl)cyclopropanecarboxam ide A40 (0.147 g, 0.465 mmol), teit-butyl 4- amino-i H-pyrazole-1-carboxylate (0.102 g, 0.559 mmol), 052003 (0.455 g, 1.40 mmol), Xantphos (0.011 g, 0.019 mmol) and Pd(OAc)2 (0.002 g, 0.009 mmol) in 1,4- dioxane (5 mL) was bubbled with N2 for 10 minutes before being heated in themicrowave for 20 minutes at 120 00 The reaction mixture was cooled to room temperature, adsorbed onto silica, and purified by column chromatography (Biotage Isolera, 24 g Si02 cartridge, 20-100% EtOAc in petroleum benzine 40-60 00 then 0- 20% MeOH in EtOAc) to give a white solid. This solid was taken up in DCM and precipitated by the addition of cyclohexane. The suspension was sonicated for 10minutes and the precipitate was isolated by vacuum filtration and washed with Et20 to give the title compound 46 as a white solid (0.021 g, 12%). LCMS-D: rt 2.98 mm; m/z 363 [M+H].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, its application will become more common.

Reference:
Patent; CANCER THERAPEUTICS CRC PTY LIMITED; FOITZIK, Richard Charles; MORROW, Benjamin Joseph; HEMLEY, Catherine Fae; LUNNISS, Gillian Elizabeth; CAMERINO, Michelle Ang; GANAME, Danny; STUPPLE, Paul Anthony; LESSENE, Romina; KERSTEN, Wilhelmus Johannes Antonius; HARVEY, Andrew John; HOLMES, Ian Peter; WO2014/26243; (2014); A1;,
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