Adding a certain compound to certain chemical reactions, such as: 152120-54-2, name is tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 152120-54-2, Recommanded Product: tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate
To a mixture of N,N’-bis(tertbutoxycarbonyl)-1H-pyrazole-1-carboxamidine (2g, 6.44 mmol), triphenylphosphine (2.53g, 9.67 mmol), MeOH (260 muL, 6.44 mmol) and dry THF (20 mL) was added dropwise DIAD ( 1.9 mL, 9.67 mmol) at 0C under argon. The reaction mixture was stirred at room temperature overnight. Then a solid was filtered off and the filtratrate was concentrated under reduced pressure. A residue was washed with hexane (6 x 50mL). Hexane was evaporated and the residue was purified by column chromatography on silica gel (hexane/AcOEt, 7: 1 to 5: 1) to give tert-butyl (((tert-butoxycarbonyl)imino)(1H-pyrazol-1-yl)methyl)(methyl)carbamate (1.49 g, 71 %) as a colorless oil . ESI+MS: m/z = 347.1 (M+1)+. 1Eta NMR (700 MHz, Chloroform-d) delta 8.02 (s, 1H), 7.71 (d, J= 1.1 Hz, 1H), 6.45 (ddd, J = 8.7, 2.7, 1.6 Hz, 1H), 3.27 (s, 3H), 1.54 (s, 9H), 1.32 (s, 9H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ONCOARENDI THERAPEUTICS SP. Z O.O.; B?ASZCZYK, Roman; BRZEZI?SKA, Joanna; GO??BIOWSKI, Adam A.; OLCZAK, Jacek; (93 pag.)WO2016/108707; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics