Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 15366-34-4, name is Methyl 1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., Product Details of 15366-34-4
To a mixture of tert-butyl 3-(methanesulfonyloxy)azetidine-l-carboxylate (750 mg, 2.98 mmol) in DMF (10 mL) was added K2C03(1.2 g, 8.95 mmol) and methyl lH-pyrazole- 3-carboxylate (376.4 mg, 2.98 mmol). The reaction was stirred at 100 C overnight. TLC showed the reaction was complete. The mixture was washed with water and extracted with EA. The organic layer was dried over anhydrous Na2S04and concentrated under reduced pressure to give methyl l-(l-(tert-butoxycarbonyl)azetidin-3-yl)-lH-pyrazole-3-carboxylate (650 mg). LC-MS (ESI) found: 236 [M+H-56]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ZAFGEN, INC.; ZAHLER, Robert; VATH, James, E.; (239 pag.)WO2019/118612; (2019); A1;,
Pyrazole – Wikipedia,
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