Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 15802-75-2, name is 4-Iodo-3-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., SDS of cas: 15802-75-2
Compound 34H and Compound 34I: 1-[3-(Benzyloxy)propyl]-4-iodo-3-methyl-1 /-/-pyrazole and 1 -[3-(benzyloxy)propyl]-4-iodo-5-methyl-1 H-pyrazoleA mixture of 3-methyl-4-iodopyrazole (2.59 g, 12.5 mmol) and 1 -bromo-3- benzyloxypropane (3.00 g, 13.1 mmol) in DMF (1 1.4 mL) was charged with potassium carbonate (2.07 g, 15.0 mmol). The reaction mixture was allowed to stir at rt for 16 hrs overnight. The reaction mixture was quenched with water and then extracted with EtOAc. The organic layer was washed with water, brine (2x), dried over sodium sulfate, filtered, and then concentrated in vacuo to yield an oil. The crude material was purified using a Teledyne ISCO Combiflash Rf system [Heptane/EtOAc (100:0? 0:100)] to afford the title products as a mixture of regioisomers (3.60 g, 41 % combined yield). The reaction was carried onto the next step without any further purification. MS (ESI): m/z = 357.02 [M+H]+. UPLC: tR = 1.62 min (UPLC-TOF: polar_3 min).
The synthetic route of 15802-75-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; OSI PHARMACEUTICALS, LLC; CREW, Andrew, P.; DONG, Hanqing; FERRARO, Caterina; SHERMAN, Dan; SIU, Kam, W.; WO2012/74951; (2012); A1;,
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