Synthetic Route of 16617-46-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of compound SI (5.0 g, 46.30 mmol) and 2-bromo-l,l- diethoxyethane (10.0 g, 50.90 mmol) in DMF (20 mL) was added K2CO3 (12.78 g, 92.60 mmol) in one portion. The reaction mixture was stirred at 80 °C overnight. After cooling to room temperature, the mixture was poured into ice water and extracted with ethyl acetate (250 mL). The organic layer was washed with brine, dried over anhydrous Na2S04, filtered and then concentrated. The residue was purified by column chromatography on silica gel (petroleum ethenethyl acetate = 100: 1 to 5: 1) to afford compound S2 (9 g, yield 90percent) as a yellow oil.
The chemical industry reduces the impact on the environment during synthesis 3-Amino-1H-pyrazole-4-carbonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (447 pag.)WO2017/35408; (2017); A1;,
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