Adding a certain compound to certain chemical reactions, such as: 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25016-20-0, COA of Formula: C5H6N2O2
Example 34 1-Methyl-N-4-[rel-(4aS,5aR)-5a-methyl-4,6-dioxo-3-(phenylamino)-1 ,4,4a,5,5a,6- hexah drocyclopropa[f]indol-2-yl]pyridin-2-yl-1 H-pyrazole-3-carboxamide A solution of 1 -methyl-1 H-pyrazole-3-carboxylic acid (1 10 mg, 871 muiotaetaomicronIota) and HATU (331 mg, 871 muiotaetaomicronIota) in DMA (3 mL) was added to a mixture of rel-(4aR,5aR)-2-(2-Aminopyridin- 4-yl)-3-anilino-5a-methyl-4a,5,5a,6-tetrahydrocyclopropa[f]indol-4(1 H)-one (26; 100 mg, 290 muiotaetaomicronIota) and DIPEA (152 muIota_, 871 muiotaetaomicronIota) in DMA (3 mL) and stirred for 16 h at 50 under an atmosphere of air. The mixture was concentrated, DCM added and washed with water and dried over sodium sulfate. After filtration and concentration the residue was purified by Biotage (SNAP NH 28 g, EtOH:DCM) to give the title compound (27 mg, 19%). 1 H-NMR (400 MHz, DMSO-de), delta [ppm]= 1 .39 (3H), 1 .58 (1 H), 1 .85 (1 H), 2.32 (1 H), 3.96 (3H), 6.53-6.61 (3H), 6.85 (1 H), 7.00 (2H), 7.38 (1 H), 7.50 (1 H), 7.88 (1 H), 8.23 (1 H), 8.52 (1 H), 9.51 (1 H), 13.13 (1 H)
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Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; GRAHAM, Keith; KLAR, Ulrich; BRIEM, Hans; SIEMEISTER, Gerhard; MOeNNING, Ursula; (145 pag.)WO2017/21348; (2017); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics