Application of 3112-31-0, A common heterocyclic compound, 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, molecular formula is C5H4N2O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a 25 mL reactor, 174.0 mg of 3,5-pyrazoledicarboxylic acid monohydrate and 250.0 mg of copper sulfate pentahydrate powder were added, 5 mL of 4-methylpyridine and 10 mL of water were added, and after stirring for 15 minutes, the reaction kettle was placed in an oven. Heating to 180 ° C, the reaction is 24 hours;After the reaction is completed, the reaction solution is transferred to a flask, and 2 mL of a saturated aqueous solution of sodium sulfide is added to the reaction solution, and after the precipitation is completed, it is filtered;adding 1M hydrochloric acid solution to the filtrate droplet obtained in the second step, adjusting the solution pH=3, and filtering;The fourth step: extracting the filtrate obtained in the third step (3×20 mL) using an organic solvent dichloromethane, collecting the organic phase, and drying with anhydrous sodium sulfate for 10 h;the organic phase obtained after the fourth step of drying was concentrated and dried to obtain 71.0 mg of a white powder, which was designated as sample 3.
The synthetic route of 3112-31-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chinese Academy Of Sciences Fujian Structure Of Matter Institute; Huang Deguang; Xiang Shiqun; Zhang Xiaofeng; (13 pag.)CN109369617; (2019); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics